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Bulletin of the National Research Centre
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Pharmaceutical Industries

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  1. Heart Study has been operating for more than 40 years, and throughout that time it has found a number of risk variables that interact negatively to have an overall negative effect on cardiovascular disease (CV...

    Authors: Shankar Gharge, Rahul Koli, Sachin Gudasi and Sushmita I. Hiremath
    Citation: Bulletin of the National Research Centre 2023 47:24
    Content type: Review Published on:

  2. Typhoid fever, a disease caused by a gram negative bacterial species known as Salmonella typhi, constitutes a significant cause of morbidity and mortality, especially in developing nations of the world. Antibioti...

    Authors: John Philip Ameji, Adamu Uzairu, Gideon Adamu Shallangwa and Sani Uba
    Citation: Bulletin of the National Research Centre 2023 47:6
    Content type: Research Published on:

  3. Blumenbachia insignis is a plant native to Brazil, Uruguay, and Argentina. It is used as an ornamental plant for its flowers, but also, in popular medicine, the stems and leaves are used as antirheumatic agents. ...

    Authors: Maria Florencia Fangio, Gonzalo Burgos Herrera, Sandra Medici, Francisco Cardinali and Cristina Lujan Ramirez
    Citation: Bulletin of the National Research Centre 2022 46:269
    Content type: Research Published on:

  4. In an attempt to prove biological activity enhancement upon escalating the cellular uptake response through ligand and carrier-based via nanoframework, gallic acid was chosen to be formulated into PLGA-based p...

    Authors: V. Sandhiya and U. Ubaidulla
    Citation: Bulletin of the National Research Centre 2022 46:234
    Content type: Research Published on:

  5. Piliostigma reticulatum is a plant traditionally used to treat malaria, smallpox, neuralgia, dysentery, diarrhea, and rheumatism in Northern Nigeria. There is no scientific evidence to support the antimalarial ac...

    Authors: Safiya Shehu Abdulkadir, Abubakar Ibrahim Jatau, Umar Sharif Abdussalam, Lawal Alhassan Bichi, Bilyaminu Abubakar and Sani Malami
    Citation: Bulletin of the National Research Centre 2022 46:223
    Content type: Research Published on:

  6. In 2003, the first case of severe acute respiratory syndrome coronavirus (SARS-CoV) was recorded. Coronaviruses (CoVs) have caused a major outbreak of human fatal pneumonia. Currently, there is no specific dru...

    Authors: David Ebuka Arthur, Benjamin Osebi Elegbe, Augustina Oyibo Aroh and Mahmoud Soliman
    Citation: Bulletin of the National Research Centre 2022 46:210
    Content type: Research Published on:

  7. High-fat diet (HFD) has been linked to oxidative stress, dyslipidaemia, obesity and cardiovascular diseases. Studies have shown that medicinal plants have antioxidant properties and may have protective effects...

    Authors: Osebhahiemen Ibukun and Ehimwenma S. Omoregie
    Citation: Bulletin of the National Research Centre 2022 46:204
    Content type: Research Published on:

  8. Cyclodextrins offer a range of biomedical applications in the pharmaceutical and biotechnology industries. Cyclodextrins (CDs) are oligosaccharides composed of glucose as repeating units (6–9 repeating units g...

    Authors: Jatinder Singh, Isha Dhamija, Harmanpreet Meehenian, Neeraj Kumar, Simran Simran, Muskan Muskan, Madan L. Verma and Sandeep Kumar
    Citation: Bulletin of the National Research Centre 2022 46:202
    Content type: Review Published on:

  9. This study evaluated the heavy metal identity and content of registered Thai Traditional medicine (TTM) preparations in Thailand to ensure consumer safety.

    Authors: Sornkanok Vimolmangkang, Dolly Rani, Naruemon Prestwong, Chayanis Sutcharitchan and Duangkamol Pakdeesattayapong
    Citation: Bulletin of the National Research Centre 2022 46:200
    Content type: Research Published on:

  10. Leishmaniasis is one of the neglected tropical diseases which is prevalent in the tropical regions of the world most especially in Africa. It is caused by the Leishmania species and transmitted to humans majorly ...

    Authors: Fabian Audu Ugbe, Gideon Adamu Shallangwa, Adamu Uzairu and Ibrahim Abdulkadir
    Citation: Bulletin of the National Research Centre 2022 46:189
    Content type: Research Published on:

  11. β-catenin is an important unit of the Wnt/β-catenin signaling pathway, a conserved process involving several physiological activities, encompassing differentiation and cell proliferation, etc. The dysfunction ...

    Authors: Ayomide Oluwadarasimi Adebesin, Abigail Oluwakemi Ayodele, Olabode Omotoso, Precious Ayorinde Akinnusi and Samuel Olawale Olubode
    Citation: Bulletin of the National Research Centre 2022 46:183
    Content type: Research Published on:

  12. Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on deprescr...

    Authors: Safiya Bala Borodo, Abubakar Ibrahim Jatau, Mustapha Mohammed, Nafiu Aminu, Zayyanu Shitu and Abubakar Sha’aban
    Citation: Bulletin of the National Research Centre 2022 46:178
    Content type: Review Published on:

  13. In spite of the significant escalation in the depth of our conception and regulation of breast cancer over the past decades, the malady is still a serious community health challenge globally and poses a substa...

    Authors: Sagiru Hamza Abdullahi, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba and Abdullahi Bello Umar
    Citation: Bulletin of the National Research Centre 2022 46:177
    Content type: Research Published on:

  14. The purpose of this research was to compare the effect of shape factors of biconvex compacts on prediction of dilution potential from polynomial regression models of area ratio-mass fraction data of novel α-la...

    Authors: Ilyasu Salim, Adeniji Kehinde Olowosulu and Abdulrahman Abdulsamad
    Citation: Bulletin of the National Research Centre 2022 46:173
    Content type: Research Published on:

  15. Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small ce...

    Authors: Karamot O. Oyediran, Margaret O. Ilomuanya, Chukwuemeka P. Azubuike and Layeni Nurudeen
    Citation: Bulletin of the National Research Centre 2022 46:167
    Content type: Review Published on:

  16. Diabetes mellitus (DM) is one of the most defying health risk in the twenty-first century promoting a high rate of morbidity and mortality that could possibly increase if no intervention is in place. However, ...

    Authors: Khalifa Sunusi Aminu, Adamu Uzairu, Abdullahi Bello Umar and Muhammad Tukur Ibrahim
    Citation: Bulletin of the National Research Centre 2022 46:162
    Content type: Research Published on:

  17. Snake envenomation is a public health problem that has caused many deaths, disabilities and significant physical, psychological and socio-economic losses worldwide. In many rural communities, some plants have ...

    Authors: Ayékotchami Jacques Dossou, Adandé Belarmain Fandohan, Timothy Omara and Joachin Gbenou
    Citation: Bulletin of the National Research Centre 2022 46:160
    Content type: Research Published on:

  18. The polymeric spherical agglomerate of Bosentan monohydrate was prepared by crystallo-co-agglomeration technique, for enhancing the micrometric properties and solubility of the drug. The agglomerates were deve...

    Authors: Umang Varia, Azad Patel, Hitesh Katariya and Krunal Detholia
    Citation: Bulletin of the National Research Centre 2022 46:156
    Content type: Research Published on:

  19. Preparation of Ipomoea asarifolia (Desr) (Convolvulaceae) is widely used in traditional African medicine for the treatments of different kinds of ailments such as syphilis, malaria, convulsions and rheumatism.

    Authors: Samaila S. Chiroma, Abdullahi B. Nazifi, Ya’u Jamilu, Aliyu Musa, Lawal A. Bichi and Samaila M. Chiroma
    Citation: Bulletin of the National Research Centre 2022 46:150
    Content type: Research Published on:

  20. The global development of innovative antimicrobial drugs and drug design techniques has been necessitated by the persistent increase of multidrug resistant infections. Regardless of advances in technology for ...

    Authors: Michael Tosin Bayode, Mercy Adewumi Alabi, Olamide Joshua Babatunde, Muyideen Enitan Sadibo, Blessing Temitope Lawani, Ayomide Faith Okiti, Michael Omoniyi Elabiyi and Damilola Israel Lawrence
    Citation: Bulletin of the National Research Centre 2022 46:149
    Content type: Review Published on:

  21. The purpose of this study was to use the MTT test to assess the cytotoxic effects of different extracts of Convolvulus pluricaulis leaves in vitro. Convolvulus pluricaulis leaf ethanolic extract has been demonstr...

    Authors: Ashpak Mubarak Tamboli and Kiran Anna Wadkar
    Citation: Bulletin of the National Research Centre 2022 46:145
    Content type: Research Published on:

  22. Medicinal plants are natural sources of antioxidants effective in the treatment of oxidative stress-mediated diseases. This study aims to evaluate the hepato-renal protective efficacy of Andrographis paniculata l...

    Authors: Abiodun Olusoji Owoade, Abdullahi Opeyemi Alausa, Adewale Adetutu and Akinade William Owoade
    Citation: Bulletin of the National Research Centre 2022 46:141
    Content type: Research Published on:

  23. Bacteremia constitutes a significant public health challenge and represents a vital cause of morbidity and mortality in HIV-infected patients, and fluoroquinolones are commonly prescribed antibiotics due to th...

    Authors: Olajide Joseph Akinjogunla, Adebowale Toba Odeyemi, Mfonobong Favour Alozie, Igbagbo Ehinmore, Unyime Effiong Ukpong, Jumbo Ediomo and Etieno Kingsley Akpanson
    Citation: Bulletin of the National Research Centre 2022 46:135
    Content type: Research Published on:

  24. Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the manageme...

    Authors: Abdullahi Balarabe Nazifi, Abdulhakim Abubakar, Mohammed Garba Magaji, Musa Aliyu and Nuhu Mohammed Danjuma
    Citation: Bulletin of the National Research Centre 2022 46:113
    Content type: Research Published on:

  25. A perusal of the literature suggested that Manilkara zapota (L.) P. Royen stem bark (MZSB) is enriched with several bioactive phytoconstituents but had not been yet screened for its in vitro and in vivo antidiabe...

    Authors: Pravin P. Karle, Shashikant C. Dhawale, Rajesh J. Mandade and Vijay V. Navghare
    Citation: Bulletin of the National Research Centre 2022 46:110
    Content type: Research Published on:

  26. Hepatitis C virus (HCV) is a contagious disease that damages the liver over time, eventually leading to cirrhosis and death. Chronic HCV infection is regarded as a serious health problem worldwide, impacting u...

    Authors: Stephen Ejeh, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi and Muhammad Tukur Ibrahim
    Citation: Bulletin of the National Research Centre 2022 46:109
    Content type: Research Published on:

  27. Belize is rich in rainforest and vast medicinal plants that have the potential for drug discoveries. Few studies have examined the use of medicinal plants in the management of chronic diseases in Belize. The p...

    Authors: David D. Mphuthi and Danladi Chiroma Husaini
    Citation: Bulletin of the National Research Centre 2022 46:107
    Content type: Research Published on:

  28. The search for ideal drugs with absolute antiviral activity against SARS-CoV-2 is still in place, and attention has been recently drawn to natural products. Several molecular targets have been identified as po...

    Authors: Precious Ayorinde Akinnusi, Samuel Olawale Olubode and Wasiu Adeboye Salaudeen
    Citation: Bulletin of the National Research Centre 2022 46:102
    Content type: Research Published on:

  29. Leishmaniasis is a neglected tropical disease caused by a group of protozoan of the genus Leishmania and transmitted to humans majorly through the bite of the female sand fly. It is prevalent in the tropical regi...

    Authors: Fabian Audu Ugbe, Gideon Adamu Shallangwa, Adamu Uzairu and Ibrahim Abdulkadir
    Citation: Bulletin of the National Research Centre 2022 46:92
    Content type: Research Published on:

  30. As a result of aberrant neural development, autism spectrum disorder (ASD) is characterised by complicated behavioural and memory issues. The dearth of knowledge about the actual etiopathology of autism makes ...

    Authors: K. N. Jiji and P. Muralidharan
    Citation: Bulletin of the National Research Centre 2022 46:71
    Content type: Research Published on:

  31. Starches have been shown to be important across various disciplines such as the pharmaceutical industries, food industries and also paper industries. Starch is basically a mixture of polymers consisting of α-d-gl...

    Authors: Ifeanyi Justin Okeke, Angus Nnamdi Oli, Chioma Miracle Ojiako, Emmanuel Chinedum Ibezim and Jude N. Okoyeh
    Citation: Bulletin of the National Research Centre 2022 46:63
    Content type: Research Published on:

  32. Antibiotic resistance has risen as a result of a variety of conditions, prompting researchers to look for new compounds that can combat multidrug-resistant organisms. Over the last two decades, chalcones have ...

    Authors: AbdulRazaq Tukur, James Dama Habila, Rachael Gbekele-Oluwa Ayo and Ogunkemi Risikat Agbeke Iyun
    Citation: Bulletin of the National Research Centre 2022 46:60
    Content type: Research Published on:

  33. Ionizing radiations causes harm to living organisms and the rapid technological progress has increased human exposure to ionizing radiations enormously. Ionizing radiations come in contact with exposure from s...

    Authors: Sarin A. Chavhan, Ravindra L. Bakal, Rahul D. Jawarkar, Roshani P. Gandhi, Mayuri P. Chandak and Israa Lewaa
    Citation: Bulletin of the National Research Centre 2022 46:48
    Content type: Review Published on:

  34. The World Health Organization declared the outbreak of the novel coronavirus (COVID-19) as a global health emergency on January 30, 2020, and as a pandemic disease on March 11, 2020. This review highlights the...

    Authors: Simran Giri, Sanjukta Sen, Rohan Singh, Paramita Paul, Ranabir Sahu, Gouranga Nandi and Tarun Kumar Dua
    Citation: Bulletin of the National Research Centre 2022 46:47
    Content type: Review Published on:

  35. Chrysophyllum albidum is a well-known medicinal plant in Africa and has many medicinal properties. This study investigated the effect of sonication, solvent polarity (acetone and ethanol), and plant matrix (bark ...

    Authors: Afolabi C. Akinmoladun, Olubusola Elizabeth Falaiye, Olubukola Benedicta Ojo, Abimbola Adeoti, Zainab Abiola Amoo and Mary Tolulope Olaleye
    Citation: Bulletin of the National Research Centre 2022 46:40
    Content type: Research Published on:

  36. Plants are the prime source of vital secondary metabolites (SMs) which are medicinally important for drug development, and these secondary metabolites are often used by plants in the various important tasks li...

    Authors: Mohammad Afaan Fazili, Irfan Bashir, Mudasar Ahmad, Ubaid Yaqoob and Syed Naseem Geelani
    Citation: Bulletin of the National Research Centre 2022 46:35
    Content type: Review Published on:

  37. Malaria is a major cause of death in tropical countries such as Nigeria. Chasmanthera dependens (Hochst) is a wild plant used by traditional healers for the treatment of malaria and other health challenges. This ...

    Authors: Conrad Kenechukwu Enenebeaku, Cynthia Ekwy Ogukwe, Christian Okechukwu Nweke, Sylvia Onyinyechi Anyado-Nwadike, Martin Obi, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku and Odangowei I. Ogidi
    Citation: Bulletin of the National Research Centre 2022 46:33
    Content type: Research Published on:

  38. Aspergillosis, has recently confounded some states of India. Due to major role in fungal cell wall synthesis, in the present study UDP-glycosyltransferase, Glucosamine-6-phosphate synthase and chitin synthase ...

    Authors: Arun Dev Sharma and Inderjeet Kaur
    Citation: Bulletin of the National Research Centre 2022 46:23
    Content type: Research Published on:

  39. Coxsackievirus group B (CVBs) are common enteroviruses associated with several diseases from etiologically to inflammatory cardiomyopathies and constitute a severe cause of mortality in newborn resulting in se...

    Authors: Babatunde Samuel Obadawo, Uchenna Asogwa and Abdualbaset Ahmed Ali
    Citation: Bulletin of the National Research Centre 2022 46:14
    Content type: Research Published on:

  41. Scientists created a new area known as "green nanotechnology" by combining the concept of sustainability with nanotechnology. Its goal is to eliminate the use of chemicals in nanoparticle manufacturing by repl...

    Authors: Habeeb Hiba and John E. Thoppil
    Citation: Bulletin of the National Research Centre 2022 46:9
    Content type: Review Published on:

  42. Cancer is a major health threat especially in unindustrialized nations. It surpasses coronary diseases and takes the number one killer position as a result of different global wide influences. Among many breas...

    Authors: Sagiru Hamza Abdullahi, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba and Abdullahi Bello Umar
    Citation: Bulletin of the National Research Centre 2022 46:2
    Content type: Research Published on:

  43. The plant Culcasia angolensis (Araceae) has diverse ethnomedicinal uses, including the management of rheumatic pain, healing of cuts, dislocations, and bruises. Despite its potential therapeutic uses, the toxicit...

    Authors: Idagu Godwin Abraham and Mubarak Hussaini Ahmad
    Citation: Bulletin of the National Research Centre 2021 45:226
    Content type: Research Published on:

  44. Caffeine is a natural alkaloid present in a variety of highly consumed popular drinks such as coffee, tea and soft drinks as well as chocolate. Its consumption elicits beneficiary psychostimulant that has been...

    Authors: Mona E. Aboutabl, Asmaa M. Salman, Amina A. Gamal el Din and Yousreya A. Maklad
    Citation: Bulletin of the National Research Centre 2021 45:219
    Content type: Research Published on:

  45. Costus speciosus (Koen) Sm. popularly known as crepe ginger or spiral ginger and insulin plant is a perennial rhizomatous herb contain variable number of medicinally important bioactive phytochemicals having inte...

    Authors: Saima Sohrab, Pratibha Mishra and Sanjay Kumar Mishra
    Citation: Bulletin of the National Research Centre 2021 45:209
    Content type: Review Published on:

  47. Africa is blessed with rich floral biodiversity which are harnessed as herbal medicines and remedies for several ailments. Since there has been evidence of organ toxicity following prolonged ingestion of medic...

    Authors: Uchechi E. Enenebeaku, Evangeline N. Okotcha, Lilian M. O. Oguoma, Ifeyinwa C. Mgbemena, Conrad K. Enenebeaku and Chiemeziem A. Onyeka
    Citation: Bulletin of the National Research Centre 2021 45:186
    Content type: Research Published on:

  48. Nanotechnology's rapid development has been in great demand, particularly for silver nanoparticles, which are useful in a variety of industries including medicine, textiles, and home appliances. Silver nanopar...

    Authors: Prashant J. Burange, Mukund G. Tawar, Ritu A. Bairagi, Vedanshu R. Malviya, Vanshika K. Sahu, Sakshi N. Shewatkar, Roshani A. Sawarkar and Renuka R. Mamurkar
    Citation: Bulletin of the National Research Centre 2021 45:181
    Content type: Review Published on:

  49. Man has a long history of utilizing herbal preparations to treat infections. Therefore, this study aimed to investigate the quantitative phytochemical components, gas chromatography–mass spectrometry analysis,...

    Authors: Kingsley Erhons Enerijiofi, Funmilayo Hannah Akapo and Joseph Omorogiuwa Erhabor
    Citation: Bulletin of the National Research Centre 2021 45:179
    Content type: Research Published on:

  50. Withania somnifera (L.) Dunal (W. somnifera) is a herb commonly known by its English name as Winter Cherry. Africa is indigenous to many medicinal plants and natural products. However, there is inadequate documen...

    Authors: Henok Kessete Afewerky, Ayeni Emmanuel Ayodeji, Bashir Bolaji Tiamiyu, Joshua Iseoluwa Orege, Emmanuel Sunday Okeke, Aanuoluwapo Opeyemi Oyejobi, Petuel Ndip Ndip Bate and Sherif Babatunde Adeyemi
    Citation: Bulletin of the National Research Centre 2021 45:176
    Content type: Review Published on: