Andrade ER, Cruz IB, Andrade VV, Piccoli JC, González-Gallego J, Barrio JP, González P (2011) Evaluation of the potential protective effects of ad libitum black grape juice against liver oxidative damage in whole-body acute X-irradiated rats. Food Chem Toxicol 49(4):1026–1032
CAS
PubMed
Google Scholar
Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, Prasad J, Singh S, Samanta N, Sharma RK (2005) Radioprotection by plant products: present status and future prospects. Phytother Res 19(1):1–22
CAS
PubMed
Google Scholar
Bailey LH (1924) Manual of cultivated plants. Macmillan Co., New York, pp 101–103
Google Scholar
Bala M, Goel HC (2004) Radioprotective effect of podophyllotoxin in Saccharomyces cerevisiae. J Environ Pathol Toxicol Oncol 23(2):139–144
CAS
PubMed
Google Scholar
Baliga MS, Haniadka R, Pereira MM, Thilakchand KR, Rao S, Arora R (2012) Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future. Food Funct 3(7):714–723
CAS
PubMed
Google Scholar
Benkovic V, Knezevic AH, Dikic D, Lisicic D, Orsolic N, Basic I, Kosalec I, Kopjar N (2008) Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay. Phytomedicine 15(10):851–858
CAS
PubMed
Google Scholar
Bhattacharya S, Subramanian M, Roychowdhury S, Bauri AK, Kamat JP, Chattopadhyay S, Bandyopadhyay SK (2005) Radioprotective property of the ethanolic extract of Piper betel Leaf. J Radiat Res 46(2):165–171
PubMed
Google Scholar
Bhattacharya S, Subramanian M, Kamat JP, Bandyopadhyay SK, Chattopadhyay S (2006) Radioprotective property of Emblica officinalis fruit ethanol extract. Pharm Biol 44(9):682–690
CAS
Google Scholar
Brown JM, Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4:437–447
CAS
PubMed
Google Scholar
Checker R, Chatterjee S, Sharma D, Gupta S, Variyar P, Sharma A, Poduval TB (2008) Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol 8(5):661–669
CAS
PubMed
Google Scholar
Choudhary D, Chandra D, Kale RK (1999) Modulation of radioresponse of glyoxalase system by curcumin. J Ethnopharmacol 64(1):1–7
CAS
PubMed
Google Scholar
Dainiak N (2002) Hematologic consequences of exposure to ionizing radiation. Exp Hematol 30(6):513–528
CAS
PubMed
Google Scholar
Emerit I, Arutyunyan R, Oganesian N, Levy A, Cernjavsky L, Sarkisian T, Pogossian A, Asrian K (1995) Radiation-induced clastogenic factors: anticlastogenic effect of Ginkgo biloba extract. Free Radic Biol Med 18(6):985–991
CAS
PubMed
Google Scholar
Faramarzi S, Piccolella S, Manti L, Pacifico S (2021) Could polyphenols really be a good radioprotective strategy? Molecules 26(16):4969. https://doi.org/10.3390/molecules26164969.PMID:34443561;PMCID:PMC8398122
Article
CAS
PubMed
PubMed Central
Google Scholar
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917
CAS
PubMed
Google Scholar
Freitas RB, González P, Martins NM, Andrade ER, Cesteros Morante MJ, Conles Picos I, Costilla García S, Bauermann LF, Barrio JP (2017) Ameliorative effect of black grape juice on systemic alterations and mandibular osteoradionecrosis induced by whole brain irradiation in rats. Int J Radiat Biol 93(2):204–213
CAS
PubMed
Google Scholar
Gaikwad PS (2010) Spinacia oleracea Linn. A pharmacogenetic and pharmacological overview. Int J Res in Ayurveda and Pharm 1(1):78–84
Google Scholar
Goel A, Curcumin ABB (2010) The golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 62(7):919–930
CAS
PubMed
Google Scholar
Goel HC, Prasad J, Singh S, Sagar RK, Agrawala PK, Bala M, Sinha AK, Dogra R (2004) Radioprotective potential of an herbal extract of Tinospora cordifolia. J Radiat Res 45(1):61–68
PubMed
Google Scholar
Gupta NK (1996) Modification of radiation induced changes in murine hepatic lipid profiles by garlic (Allium sativum Linn.) unsaturated oils. Indian J Exp Biol 34(9):851–853
CAS
PubMed
Google Scholar
Hall E, Giaccia A (2006) Radiobiology for the radiologist, 6th edn. Lippincott Williams & Wilkins, Philadelphia
Google Scholar
Hanumakumar GE, Balaji M, Karunakaran RS (2018) Enhanced human exposure to radiations, role of phytochemicals as potential radio-protectants: a review. Int J Pharm Sci Res 9(7):2656–2668
CAS
Google Scholar
Hosseinimehr SJ (2007) Trends in the development of radioprotective agents. Drug Discov Today 12(19–20):794–805
CAS
PubMed
Google Scholar
Hosseinimehr SJ, Zakaryaee V, Froughizadeh M (2006) Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells. Mol Cell Biochem 287(1–2):193–199
CAS
PubMed
Google Scholar
Iyer D, Devi PU (2009) Radioprotective activity of Murraya koenigii (l.) on cellular antioxidants in swiss albino mice. J Pharm Res 2(3):495–501
CAS
Google Scholar
Jagetia GC (2007a) Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr 40(2):74–81
CAS
Google Scholar
Jagetia GC (2007b) Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol 595:301–320
PubMed
Google Scholar
Jagetia GC, Baliga MS (2002) Influence of the leaf extract of Mentha arvensis Linn. (mint) on the survival of mice exposed to different doses of gamma radiation. Strahlenther Onkol 178(2):91–98
PubMed
Google Scholar
Jagetia GC, Venkatesh P (2005) Radioprotection by oral administration of Aegle marmelos (L.) Correa in vivo. J Environ Pathol Toxicol Oncol 24(4):315–332
PubMed
Google Scholar
Jagetia GC, Venkatesha VA (2006) Treatment of mice with stem bark extract of Aphanamixis polystachya reduces radiation-induced chromosome damage. Int J Radiat Biol 82(3):197–209
CAS
PubMed
Google Scholar
Jagetia GC, Baliga MS, Venkatesh P, Ulloor JN (2003) Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res 160(5):584–592
ADS
CAS
PubMed
Google Scholar
Jagetia GC, Venkatesh P, Baliga MS (2004) Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol 80(4):281–290
CAS
PubMed
Google Scholar
Jena G, Vikram A, Tripathi DN, Ramarao P (2010) Use of chemoprotectants in chemotherapy and radiation therapy: the challenges of selecting an appropriate agent. Integr Cancer Ther 9(3):253–258
PubMed
Google Scholar
Kadam US, Ghosh SB, De S, Suprasanna P, Devasagayam TPA, Bapat VA (2008) A antioxidant activity in sugarcane juice and its protective role against radiation induced DNA damage. Food Chem 106:1154–1160
CAS
Google Scholar
Kamat JP, Boloor KK, Devasagayam TP, Venkatachalam SR (2000) Antioxidant properties of Asparagus racemosus against damage induced by gamma-radiation in rat liver mitochondria. J Ethnopharmacol 71(3):425–435
CAS
PubMed
Google Scholar
Kovalenko PG, Antonjuk VP, Maluita SS (2003) Secondary metabolites production from transformed cells of Glycyrrhiza glabra and Potentil laalba producents of radioprotective compounds. Ukr Biorgan Acta 1:1–17
Google Scholar
Kumar A, Ram J, Samarth RM, Kumar M (2005) Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice. Phytomedicine 12(4):285–293
CAS
PubMed
Google Scholar
Lee TK, Johnke RM, Allison RR, O’Brien KF, Dobbs LJ Jr (2005) Radioprotective potential of ginseng. Mutagenesis 20(4):237–243
CAS
PubMed
Google Scholar
Lee MT, Lin WC, Yu B, Lee TT (2017) Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals—a review. Asian-Australas J Anim Sci 30(3):299–308
CAS
PubMed
Google Scholar
Liu W, Chen Q, Wu S, Xia X, Wu A, Cui F, Gu YP, Zhang X, Cao J (2015) Radioprotector WR-2721 and mitigating peptidoglycan synergistically promote mouse survival through the amelioration of intestinal and bone marrow damage. J Radiat Res 56(2):278–286
CAS
PubMed
PubMed Central
Google Scholar
Maria OM, Eliopoulos N, Muanza T (2017) Radiation-induced oral mucositis. Front Oncol 7:89
PubMed
PubMed Central
Google Scholar
Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz BM, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, Taniguchi CM (2019) Enteral activation of WR-2721 mediates radioprotection and improved survival from lethal fractionated radiation. Sci Rep 9(1):1949
ADS
PubMed
PubMed Central
Google Scholar
Mun GI, Kim S, Choi E, Kim CS, Lee YS (2018) Pharmacology of natural radioprotectors. Arch Pharm Res 41(11):1033–1050. https://doi.org/10.1007/s12272-018-1083-6. Erratum in: Arch Pharm Res 42:732–734, 2019; Erratum in: Arch Pharm Res 43(2):272–274, 2020
Nada AS, Hawas AM, Nel-D A, Elnashar MM, AbdElmageed ZY (2012) Radioprotective effect of Curcuma longa extract on γ-irradiation-induced oxidative stress in rats. Can J Physiol Pharmacol 90(4):415–423
CAS
PubMed
Google Scholar
Naik GH, Priyadarsini KI, Naik DB, Gangabhagirathi R, Mohan H (2004) Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 11(6):530–538
CAS
PubMed
Google Scholar
Ni Y, Zhao B, Hou J, Xin W (1996) Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals. Neurosci Lett 214(2–3):115–118
CAS
PubMed
Google Scholar
Obrador E, Salvador R, Villaescusa JI, Soriano JM, Estrela JM, Montoro A (2020) Radioprotection and radiomitigation: from the bench to clinical practice. Biomedicines 8(11):461
CAS
PubMed Central
Google Scholar
Parihar VK, Dhawan J, Kumar S, Manjula SN, Subramanian G, Unnikrishnan MK, Rao CM (2007) Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice. Chem Biol Interact 170(1):49–58
CAS
PubMed
Google Scholar
Patt HM, Tyree EB, Straube RL, Smith DE (1949) Cysteine protection against X irradiation. Science 110(2852):213–214
ADS
CAS
PubMed
Google Scholar
Pereira MM, Haniadka R, Chacko PP, Palatty PL, Baliga MS (2011) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review. J BUON 16(3):414–424
CAS
PubMed
Google Scholar
Rao AV, Devi PU, Kamath R (2001) In vivo radioprotective effect of Moringa oleifera leaves. Indian J Exp Biol 39(9):858–863
CAS
PubMed
Google Scholar
Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN (1995) A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 3(1):99–109
Google Scholar
Sajikumar S, Goel HC (2003) Podophyllum hexandrum prevents radiation-induced neuronal damage in postnatal rats exposed in utero. Phytother Res 17(7):761–766
CAS
PubMed
Google Scholar
Samarth RM (2007) Protection against radiation induced hematopoietic damage in bone marrow of Swiss albino mice by Mentha piperita (Linn). J Radiat Res 48(6):523–528
PubMed
Google Scholar
Samarth RM, Samarth M (2009) Protection against radiation-induced testicular damage in Swiss albino mice by Mentha piperita (Linn.). Basic Clin Pharmacol Toxicol 104(4):329–334
CAS
PubMed
Google Scholar
Sato Y, Ohta S, Shinoda M (1990) [Studies on chemical protectors against radiation XXXI. Protection effects of Aloe arborescens on skin injury induced by X-irradiation]. Yakugaku Zasshi 110(11):876–884 (in Japanese)
CAS
PubMed
Google Scholar
Sharma J, Sharma R (2002) Radioprotection of Swiss albino mouse by Centella asiatica extract. Phytother Res 16(8):785–786
PubMed
Google Scholar
Singh SP, Abraham SK, Kesavan PC (1995) In vivo radioprotection with garlic extract. Mutat Res 345(3–4):147–153
CAS
PubMed
Google Scholar
Singh I, Sharma A, Nunia V, Goyal PK (2005) Radioprotection of swiss albino mice by Emblica officinalis. Phytother Res 19(5):444–446
PubMed
Google Scholar
Sudheer Kumar M, Unnikrishnan MK, Uma Devi P (2003) Effect of 5-aminosalicylic acid on radiation-induced micronuclei in mouse bone marrow. Mutat Res 527(1–2):7–14
CAS
PubMed
Google Scholar
Sunila ES, Kuttan G (2005) Protective effect of Piper longum fruit ethanolic extract on radiation induced damages in mice: a preliminary study. Fitoterapia 76(7–8):649–655
CAS
PubMed
Google Scholar
Tilak JC, Devasagayam TPA, Adhikari S (2003) Radioprotective and antioxidant properties of Indian medicinal plant, Terminalia arjuna. BARC Newslett 249:169–176
Google Scholar
Uma Devi P, Satish Rao BS, Kamath R (1998) A method to score micronuclei in vivo using cytochalasin B-induced cytokinesis block. Mutat Res 401(1–2):33–37
CAS
PubMed
Google Scholar
Uma Devi P, Ganasoundari A, Rao BS, Srinivasan KK (1999) In vivo radioprotection by ocimum flavonoids: survival of mice. Radiat Res 151(1):74–78
ADS
CAS
PubMed
Google Scholar
Upadhyay AK, Chacko AR, Gandhimathi A, Ghosh P, Harini K, Joseph AP, Joshi AG, Karpe SD, Kaushik S, Kuravadi N, Lingu CS, Mahita J, Malarini R, Malhotra S, Malini M, Mathew OK, Mutt E, Naika M, Nitish S, Pasha SN, Raghavender US, Rajamani A, Shilpa S, Shingate PN, Singh HR, Sukhwal A, Sunitha MS, Sumathi M, Ramaswamy S, Gowda M, Sowdhamini R (2015) Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. BMC Plant Biol 15:212
PubMed
PubMed Central
Google Scholar
Veerapur VP, Prabhakar KR, Parihar VK, Kandadi MR, Ramakrishana S, Mishra B, Satish Rao BS, Srinivasan KK, Priyadarsini KI, Unnikrishnan MK (2009) Ficus racemosa stem bark extract: a potent antioxidant and a probable natural radioprotector. Evid Based Complement Alternat Med 6(3):317–324
CAS
PubMed
Google Scholar
Verma SP, Tripathi VC, Das P (2014) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death. Asian Pac J Cancer Prev 15(5):1937–1941
PubMed
Google Scholar