Medicine and Human Genetics
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Citation: Bulletin of the National Research Centre 2024 48:23
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Pulmonary hemorrhage as a presentation of AL amyloidosis secondary to multiple myeloma: a case report
The convergence of pulmonary hemorrhage, pulmonary amyloidosis, and multiple myeloma is uncommon. Amyloidosis can affect the pulmonary parenchyma in a diffuse, tracheobronchial, or parenchymal pattern and may ...
Citation: Bulletin of the National Research Centre 2024 48:17 -
Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting
Tobacco smoking remains a major preventable cause of disease and death worldwide. Combustible cigarettes release thousands of chemicals that can initiate inflammatory pathways leading to smoking-related illnes...
Citation: Bulletin of the National Research Centre 2024 48:16 -
Patient, health professional and psychiatrist satisfaction with emergency department telepsychiatry during the COVID-19 pandemic: a pilot study
Emergency department telepsychiatry (EDTP) can improve healthcare delivery. However, no studies document implementation and overall satisfaction within the Canadian pandemic context. The objectives of this stu...
Citation: Bulletin of the National Research Centre 2024 48:10 -
Endovascular treatment of splenic artery aneurysm rupture: case report
Splenic artery aneurysms are rare and usually asymptomatic, with a high risk of mortality once they get ruptured. This is a rare case of a spontaneous splenic artery aneurysm rupture in a high-risk patient for...
Citation: Bulletin of the National Research Centre 2024 48:9 -
Utility of dipstick urinalysis in the diagnosis of urinary tract infections among outpatients in Mwanza and Dar es Salaam regions in Tanzania
Globally, urinary tract infections (UTIs) are the leading cause of hospital visits, especially among women. In many developing countries, especially in lower health facilities, the dipstick urinalysis is the m...
Citation: Bulletin of the National Research Centre 2024 48:6 -
Penile fracture with urethral injury: a case report of rare double trouble
A penile fracture occurs when the tunica albuginea of penis tears during erection. Penile fracture is a rare but serious injury that occurs when the erect penis sustains a traumatic force. It is characterized ...
Citation: Bulletin of the National Research Centre 2023 47:181 -
Tracheo-innominate fistula as a late complication of prolonged intubation in a patient with mycobacterium tuberculosis: a case report
The tracheo-innominate fistula is a rare and potentially life-threatening entity that occurs in approximately less than 1% of patients after a tracheostomy. It occurs when the anterior wall of the trachea erod...
Citation: Bulletin of the National Research Centre 2023 47:180 -
In vitro mitochondrial and myogenic gene expression is influenced by formoterol in human myotubes
Exercise is an effective treatment for establishing and maintaining skeletal muscle health. The interconnected cascade of gene expression pathways related to myogenesis, mitochondrial homeostasis, and thyroid ...
Citation: Bulletin of the National Research Centre 2023 47:178 -
Connective tissue involvement in an m.10191 T > C carrier with Leigh-like syndrome
Connective tissue involvement in a mitochondrial disorder has been only rarely reported.
Citation: Bulletin of the National Research Centre 2023 47:177 -
Prevalence of malaria infection and factors associated among HIV-infected adult patients attending HIV care and treatment clinic at Kitete regional referral hospital in Tabora region, Tanzania: a cross-sectional study
HIV and malaria are serious public health concerns, particularly in Tanzania. HIV-infected individuals are more likely to get malaria and its complications. However, data on the interaction of the two diseases...
Citation: Bulletin of the National Research Centre 2023 47:176 -
Two cases of vitamin B12 deficiency in patients with beta-thalassemia trait: lessons in diagnosis
Coexisting pathologies is not a new phenomenon and can cause diagnostic difficulties when they overshadow one another. They may alter the cytomorphology of cells and the machine readings to an extent that the ...
Citation: Bulletin of the National Research Centre 2023 47:175 -
Hypoglycemia rates and glycemic hormonal response after laparoscopic Roux-en-Y gastric bypass versus sleeve gastrectomy: a meta-analysis of comparative studies
This study aims to quantify the difference between Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) concerning the incidence of post-bariatric surgery hypoglycemia (PBSH) and variation...
Citation: Bulletin of the National Research Centre 2023 47:172 -
A case of tongue swelling after S-1, oxaliplatin, and trastuzumab for HER2-positive gastric cancer
We report a case of a patient with HER2-positive gastric cancer with marked tongue swelling during the second cycle of S-1, oxaliplatin, and trastuzumab.
Citation: Bulletin of the National Research Centre 2023 47:171 -
Diagnosis, treatment, and prevention of community-acquired pneumonia in children: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’
We recently adapted a guideline for Community-Acquired Pneumonia (CAP) in children to the Egyptian health system. Adaptation of evidence-based clinical practice guidelines to the local healthcare context is a ...
Citation: Bulletin of the National Research Centre 2023 47:169 -
A look back at the prodromal findings in Parkinson’s disease
Parkinson's disorder is a neurodegenerative illness that displays motor and non-motor manifestations. There is no definite cause of Parkinson's disorder, nor is there a medicine or treatment to prevent it.
Citation: Bulletin of the National Research Centre 2023 47:167 -
Evidence-based Egyptian clinical practice guidelines: for the prevention and management of iron deficiency and iron deficiency anemia in infants, children and adolescents
Iron deficiency (ID) is the most common nutritional disorder affecting all age groups. Infants and young children are vulnerable to anemia especially iron deficiency anemia (IDA), which represents a public hea...
Citation: Bulletin of the National Research Centre 2023 47:162 -
Diagnosis of testicular torsion with preserved blood flow detected by color Doppler ultrasonography
To diagnose testicular torsion promptly and accurately when diagnosis of testicular torsion is difficult by color Doppler ultrasonography owing to testicular blood flow, we assess the helpfulness of physical f...
Citation: Bulletin of the National Research Centre 2023 47:161 -
Microsatellite instability screening in colorectal carcinoma: immunohistochemical analysis of MMR proteins in correlation with clinicopathological features and Ki-67 protein expression
Defects in mismatch repair (MMR) system or microsatellite instability (MSI) and detected in colorectal carcinoma (CRC), both in sporadic and more frequently in hereditary cases. Immunohistochemistry (IHC) is t...
Citation: Bulletin of the National Research Centre 2023 47:155 -
A plagiarism paperdemic: determining plagiarism among COVID-19 articles in infectious disease journals between 2020 and 2021
The COVID-19 pandemic has caused drastic changes in the publishing framework which allowed for the quick review and rapid publication of manuscripts in order to quickly share vital information about this new v...
Citation: Bulletin of the National Research Centre 2023 47:151 -
The modulation of carbohydrate intake and intermittent fasting in obese Saudi women: a pilot study
In recent years, the prevalence of overweight and obesity has increased, leading to the development of various dietary interventions as potential treatments. Two popular diets are time-restricted feeding and l...
Citation: Bulletin of the National Research Centre 2023 47:146 -
Update on prevalence and antimicrobial resistance of Staphylococcus aureus and Pseudomonas aeruginosa isolated from diabetic foot ulcers in Africa: a systematic review and meta-analysis
Diabetes mellitus is increasing in Africa, and diabetes-related amputations exacerbated by diabetic foot infection are also prevalent with Staphylococcus aureus and Pseudomonas aeruginosa two priority pathogens p...
Citation: Bulletin of the National Research Centre 2023 47:145 -
Non-alcoholic steatohepatitis in pregnancy: a case report
Dyslipidemia and non-alcoholic fatty liver disease are well-known diseases and are part of a very broad spectrum evolving toward non-alcoholic steatohepatitis (NASH). This entity has not been described in preg...
Citation: Bulletin of the National Research Centre 2023 47:136 -
Progress in treating migraines: promising prospects for a better tomorrow
Migraine is a debilitating disorder that undoubtedly has a significant impact both clinically and socially. New treatment options are necessary in Iran due to issues with tolerance, interactions, contraindicat...
Citation: Bulletin of the National Research Centre 2023 47:128 -
The impact of COVID-19 infection on heart transplant function
Heart transplant recipients are a subset of immunocompromised patients at particularly high risk of morbidity and mortality from COVID-19. Acute effects of the viral infection have been well-described in the l...
Citation: Bulletin of the National Research Centre 2023 47:127 -
Needs and contents of a customized digital tool for retention in care and medication adherence among pregnant and breastfeeding women living with HIV in Kilimanjaro
Retention in care and adherence to medication among pregnant and breastfeeding women living with HIV (PBWLH) are crucial for preventing mother-to-child transmission (PMTCT) of HIV. Wide coverage of mobile phon...
Citation: Bulletin of the National Research Centre 2023 47:125 -
Is microbiota a part of obesogenic memory? Insights about the role of oral and gut microbiota in re-obesity
Weight re-gain (which is also known as re-obesity) is an overwhelming challenge many dieters face in their pursuit to maintain consistent results following successful weight loss. This frustrating pattern of w...
Citation: Bulletin of the National Research Centre 2023 47:124 -
Isothermal calorimetry calscreener in the metabolism gauge of human malignant neoplastic cells: a burgeoning nexus in cancer biochemical metrology and diagnostics
At present, the function of isothermal microcalorimetry (IMC) calscreener in detecting alterations in the metabolic pathways of cancer cells remains unexplored. We disclosed the shortcomings of current screeni...
Citation: Bulletin of the National Research Centre 2023 47:120 -
Tertiary referral hospital experience of methanol poisoning in the COVID-19 era: a cross-sectional study in Northwestern Iran
Methanol poisoning is a worldwide phenomenon that has resulted in deaths and irreversible complications. However, studies show it is more prevalent in developing countries and areas with lower socioeconomic st...
Citation: Bulletin of the National Research Centre 2023 47:119 -
Blastic plasmacytoid dendritic cell neoplasm: challenges in diagnosis and treatment with potential of venetoclax as an alternative to vincristine in high-risk patients—a case report
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and challenging cancer for diagnosis and treatment. Accurate diagnosis plays a crucial role guiding appropriate treatment, typically involving hig...
Citation: Bulletin of the National Research Centre 2023 47:117 -
Healthcare facilities recovering from the COVID-19 pandemic now struggling to contain the spread of infectious diseases in Africa
Citation: Bulletin of the National Research Centre 2023 47:109 -
Advanced gynecologic malignancy identified after acute stroke case report
Endometrial carcinosarcomas are rare and carry a very poor prognosis. They usually present with extensive lymphatic spread. An acute presentation of a stroke may reveal the underlying diagnosis.
Citation: Bulletin of the National Research Centre 2023 47:108 -
A pigmentary manifestation associated with PPP2R5D-related neurodevelopmental disorder: a case report and review of literature
The protein phosphatase 2 (PP2A) is one of the major serine/threonine phosphatases in humans. The most frequently reported pathogenic PP2A variants have been identified in PPP2R5D, encoding the regulatory subunit...
Citation: Bulletin of the National Research Centre 2023 47:106 -
Astrocytes’ innate role in neurodegenerative disorders
Central nervous system (CNS) astrocytes have various functions in the central nervous system (CNS). Many neurodegenerative diseases are associated with astrocyte dysfunction.
Citation: Bulletin of the National Research Centre 2023 47:105 -
Spinal cord injury without radiologic abnormality: an updated systematic review and investigation of concurrent concussion
Systematic review.
Citation: Bulletin of the National Research Centre 2023 47:103 -
A joinpoint regression model to determine COVID-19 virulence due to vaccination programme in India: a longitudinal analysis from 2020 to 2022
In late 2019, coronavirus disease, an acute respiratory illness caused by the novel coronavirus (SARS-CoV-2), was designated COVID-19 and declared a pandemic. The interim guidance for prevention is through vol...
Citation: Bulletin of the National Research Centre 2023 47:100 -
Marburg virus outbreaks in Africa
Marburg virus disease (MVD) is a zoonotic viral hemorrhagic illness, caused by a negative sense, single-stranded RNA virus which has an envelope. The Marburg virus belongs to the genus Marburgvirus of the family
Citation: Bulletin of the National Research Centre 2023 47:96 -
Neurosarcoidosis in a young male presenting with intractable migraines, blurry vision, and other nonspecific neurological symptoms case report
Neurosarcoidosis can have various neurological outcomes and presentations. It is an uncommon diagnosis, especially in young Caucasian males presenting with predominantly migraine headaches.
Citation: Bulletin of the National Research Centre 2023 47:92 -
Adapting global evidence-based practice guidelines to the Egyptian healthcare context: the Egyptian Pediatric Clinical Practice Guidelines Committee (EPG) initiative
In Egypt, academic organizations, professional societies, and research groups develop clinical practice guidelines (CPGs) in order to improve patient quality care and safety. Although important improvements ha...
Citation: Bulletin of the National Research Centre 2023 47:88 -
A persistent median artery piercing the median nerve: a review and clinical implications
This case report documents a rare variation of a persistent median artery. Normally a transient vessel present during embryologic development of the limbs, the median artery typically regresses by the eighth w...
Citation: Bulletin of the National Research Centre 2023 47:81 -
Gait analysis of patients with Parkinson-plus syndromes: a research article
Aim of the observational study was to assess which of the gait and balance parameters are most affected in Parkinson-plus syndromes patients with falling tendencies as compared to healthy individuals.
Citation: Bulletin of the National Research Centre 2023 47:76 -
Assessment of estimated low-density lipoprotein-cholesterol (LDL-c) equations: a systematic review and meta-analysis
Low-density lipoprotein cholesterol (LDL-c) is the major determinant of cardiovascular disease burden. This study critically reviewed the published literature and performed a meta-analysis to compare and to de...
Citation: Bulletin of the National Research Centre 2023 47:71 -
Spontaneous adverse drug reaction reporting during the seasonal malaria chemoprevention campaign in 2022
Seasonal administration of antimalaria drug, sulphadoxine/pyrimethamine plus amodiaquine to children 3–59 months is a malaria preventive intervention used for the reduction of childhood malaria morbidity and m...
Citation: Bulletin of the National Research Centre 2023 47:67 -
Relationship between continuous glucose monitor (CGM)-assessed glycemic health and biological markers of cardiovascular health in adults
Adults with overweight or obesity have a higher risk of the development of impaired glycemic health and cardiometabolic disorders. Glycemic variability acts as a more sensitive assessment of glycemic health co...
Citation: Bulletin of the National Research Centre 2023 47:64 -
Superbugs: a constraint to achieving the sustainable development goals
Antimicrobial resistance has already emerged as a major concern not only for public health but also for global economy. It causes a multifaceted crisis in development and growth by increasing the number of inf...
Citation: Bulletin of the National Research Centre 2023 47:63 -
A case of multidrug-resistant miliary tuberculosis mimicking lymphoma: a matter of life or death
Tuberculosis (TB) is a systemic infectious disease that is caused by Mycobacterium tuberculosis and which can affect many tissues and organs. Despite the development of curative and preventive therapies in rec...
Citation: Bulletin of the National Research Centre 2023 47:62 -
Simplified screening and referral protocol for sinonasal mucormycosis in post COVID-19 patients
To study incidence of sinonasal mucormycosis in active and post COVID-19 patients in a district-level hospital in India and develop a simplified screening and referral protocol for use at peripheral centres to...
Citation: Bulletin of the National Research Centre 2023 47:58 -
Partial detachment of the aorta: a fatal complication of CPR chest compressions
Partial aorta detachment is a rare and fatal complication of mechanical chest compression.
Citation: Bulletin of the National Research Centre 2023 47:57 -
Predominance of multidrug-resistant bacteria causing urinary tract infections among men with prostate enlargement attending a tertiary hospital in Dar es Salaam, Tanzania
Patients with prostate enlargement have an increased risk of recurrent urinary tract infections. This study determined the resistance profile of bacteria causing urinary tract infection (UTI) and the magnitude...
Citation: Bulletin of the National Research Centre 2023 47:54 -
Rethinking the syndemic of tuberculosis and dysglycaemia: a Kenyan perspective on dysglycaemia as a neglected risk factor for tuberculosis
The END TB 2035 goal has a long way to go in low-income and low/middle-income countries (LICs and LMICs) from the perspective of a non-communicable disease (NCD) control interaction with tuberculosis (TB). The...
Citation: Bulletin of the National Research Centre 2023 47:53