Kidney dysfunction is a major cause of morbidity and mortality whose prevalence, mainly because of population ageing, is rising worldwide. Also the epidemics of abnormalities clustering with insulin resistance might have played a role in increasing the prevalence of kidney dysfunction. Insulin resistance has been associated with increased risk of cardiovascular events and mortality in multiple large community-based cohort studies.
The aim of the study is to prove that insulin resistance not only may have a role in the development of chronic kidney disease but also may have a role in acute kidney injury.
This was a case-control study. The cases of the study were taken from the medical intensive care unit (ICU) of the Faculty of Medicine Cairo University, 100 control patients stratified by age and gender and 219 critically ill ICU patients with AKI.
In the current study, we find that there is statistically significant higher fasting insulin levels and higher levels Homa IR in patients with AKI than patients without AKI. These results signify that patients with AKI had insulin resistance. In our study, the Homa IR showed non-significant correlation with APACHE and SOFA score. While fasting insulin level shows significant correlation only with SOFA score after 96 h.
Our present observations indicate that patients with acute kidney injury have statistically significant higher insulin resistance.