- Review
- Open access
- Published:
Exploring Ayurveda: principles and their application in modern medicine
Bulletin of the National Research Centre volume 48, Article number: 77 (2024)
Abstract
Background
The integration of Ayurveda, Yoga, Unani, Siddha, and Homeopathy (AYUSH) with modern medicine aims to provide a more personalized and effective approach to healthcare. Ayurveda is a traditional medicine system in India that emphasizes the balance between mind, body, and spirit. It is based on the belief that every individual is unique and requires personalized treatment. The fundamental principles of Ayurveda revolve around maintaining equilibrium among three doshas: Vata (air and space), Pitta (fire and water), and Kapha (earth and water). Imbalances in these doshas are believed to cause diseases.
Main body of the abstract
The integration of Ayurveda with modern medicine seeks to utilize the best of both systems, focusing on using natural remedies and treatments that have been used for centuries in Ayurveda. The integration involves combining the strengths of both systems, including the use of Ayurvedic principles in modern medicine and the incorporation of modern medicine into Ayurvedic practices. Several studies have explored the efficacy of Ayurvedic treatments for various diseases, and the integration of Ayurvedic principles into modern medicine can provide a more comprehensive approach to patient care.
Short conclusion
Ayurveda is a traditional medical system deeply rooted in Indian culture that offers a holistic approach to healthcare. Its principles emphasize personalized treatment based on an individual's constitution. Integrating Ayurveda with modern medicine can enhance patient care by providing a more comprehensive approach towards health management. However, challenges exist regarding the standardization of Ayurvedic practices due to variations in formulations and the need for more scientific evidence for some treatments. Further studies are needed for validation purposes.
Background
Ayurveda, also known as the “Science of Life,” is an ancient system of medicine that originated in India over 5000 years ago. It is contemplated one of the oldest healthcare classifications in the world and has been practiced continuously throughout history (Lohiya et al. 2016). Ayurveda encompasses a holistic approach to health and well-being, focusing on the balance between mind, body, and spirit. Ayurveda, an ancient healing system originating in India, has an opulent history spanning thousands of years. Its roots can be traced back to Vedic scriptures, including the Atharva Veda, Rig Veda, and Yajur Veda. Ayurvedic texts, such as the Charaka Samhita and the Sushruta Samhita, compiled between 1000 and 500 BCE, serve as foundational sources for this traditional medical system (Narayana and Durg 2021; Singh and Agarwal 2022). These texts provide a comprehensive understanding of human anatomy, physiology, pathology, and therapeutic interventions. Ayurveda adopts a holistic approach to health and well-being, considering the physical, mental, and spiritual aspects of an individual. It emphasizes the dynamic balance between doshas (bio-energies), dhatus (body tissues), and malas (waste products) in maintaining health. Ayurvedic practitioners aim to restore this balance through various therapeutic modalities and lifestyle adjustments (Singh et al. 2021).
Fundamental principles
Panchakarma
Panchakarma is a central tenet of Ayurveda that involves a series of detoxification procedures to cleanse the body and mind. A holistic medical regimen called panchakarma purifies and revitalises the body, mind, as well as consciousness. It is founded on Ayurvedic principles, according to which each human is a unique phenomenon that is expressed through one of the five elements: Earth, Air, Fire, Water, and Ether. Each person has a different balance of the three doshas (tridosha) that are formed by these elements: Pitta, Kapha, and Vata. Disturbances in this doshic balance give rise to chaos and, ultimately, disease. Panchakarma is individualized for each individual founded on their unique constitution and disease, necessitating careful monitoring and oversight. It includes cleansing techniques (Shodanas) after pre-purification steps like Snehan and Svedana. It comprises five primary therapies, which are briefly described in Fig. 1.
Tridosha theory
One fundamental idea in Ayurveda that reflects a straightforward yet profound perspective on health is the Tridosha hypothesis. It asserts that the three basic energies—Pitta, Kapha, and Vata—that regulate all physiological processes are known as doshas. The various doshas that each person possesses in different amounts are what give humans their unique physical characteristics, personalities, and susceptibilities to illness. Ayurveda offers a variety of methods for balancing the doshas, such as Panchakarma, herbal remedies, dietary adjustments, and lifestyle changes (Fig. 2).
Therapeutic modalities
Ayurvedic medicine utilizes a vast array of herbs, spices, and plant extracts for therapeutic purposes. These herbal remedies are formulated into various preparations, including decoctions, infusions, pills, powders, and oils. Common herbs used in Ayurveda include turmeric, ginger, holy basil, neem and ashwagandha (Singh et al. 2022a, b, c, d; Wu et al. 2021). A few well-known Indian medicinal plants and their applications are included in Table 1.
Ayurvedic dietary guidelines are based on the principle of Ahara (proper nourishment). A balanced diet is essential for maintaining optimal health. Specific dietary recommendations are made according to an individual's dosha constitution and health condition. Ayurvedic massage, known as Abhyanga, involves massaging the body with medicated oils (Al Mahmud et al. 2023). It helps improve circulation, ease muscle tension, and promote relaxation. Specialized massage techniques, such as Shirodhara (pouring oil on the forehead), are also employed for specific health concerns. Ayurveda emphasizes the integration of yoga and meditation practices to enhance overall well-being. Yoga postures, breathing exercises, and meditation techniques are recommended to balance doshas, promote mental clarity, and reduce stress (Kakodkar et al. 2021). Ayurveda advocates for a harmonious lifestyle that aligns with the rhythms of nature. Regular exercise, adequate sleep, and stress management are essential components of Ayurvedic health maintenance. Ayurveda has gained global recognition for its holistic approach to health and well-being. It offers a comprehensive system that addresses the root causes of imbalances rather than merely treating them (Singh et al. 2022b; Verma et al. 2024).
Historical development
The origins of Ayurveda could be trailed back to the Vedic period in ancient India when sages and seers documented their knowledge of health and healing in sacred texts called Vedas. These texts, particularly the Atharva Veda, contain detailed descriptions of various diseases, their causes, symptoms, and treatments (Sharma et al. 2022). Over time, Ayurveda evolved and expanded its scope through the contributions of renowned scholars such as Charaka and Sushruta. Sushruta Samhita and Charaka Samhita are two seminal texts that provide comprehensive guidelines for diagnosis, treatment, and prevention of diseases (Singh et al. 2022e). Ayurveda, a Sanskrit term meaning “science of life,” is a holistic system of medicine with its roots in ancient India. Ayurveda accentuates the equilibrium between body, spirit, and mind and uses natural herbs, diet, and lifestyle changes to promote health and prevent disease. Here is a detailed historical timeline of Ayurveda's development in India:
Early Vedic period (1500–1000 BCE)
The earliest evidence of Ayurvedic practices can be found in the ancient Vedic texts, such as the Rigveda, Atharvaveda, and Yajurveda. These texts mention medicinal herbs, surgical procedures, and guidelines for healthy living. Ayurveda was closely associated with religion and spirituality, with many healing rituals performed by priests and healers in temples.
Classical period (1000–500 BCE)
During this period, Ayurveda experienced significant advancements, and several influential texts were composed. The most important of these texts are the Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya. These texts provided a comprehensive framework for Ayurvedic medicine, covering topics such as anatomy, physiology, pathology, diagnosis, and treatment. The Sushruta Samhita, in particular, is acknowledged for its contributions to surgery, including descriptions of over 120 surgical instruments and procedures(Pandey et al. 2013; Shi et al. 2021).
Pre-classical period (500–300 BCE)
This period saw the emergence of various schools of Ayurvedic thought, each with its own unique methodology for treatment and diagnosis. The most prominent schools were the Charaka School, the Sushruta School, and the Vagbhata School. Despite their differences, these schools shared a common belief in the importance of a balanced diet, herbal remedies, and lifestyle changes for maintaining health (Jaiswal and Williams 2016).
Golden age of Ayurveda (300–1000 CE)
This period marked the pinnacle of Ayurvedic development, with significant contributions from renowned physicians and scholars. Notable figures during this time include Nagarjuna, Charaka, and Sushruta. Ayurveda was widely practiced throughout India, and Ayurvedic texts were translated into several languages, including Arabic and Persian. Ayurvedic practitioners also began to establish medical schools, hospitals, and dispensaries(Honwad 2017).
Decline of Ayurveda (1000–1500 CE)
The rise of allopathic medicine and the influence of foreign invaders led to a decline in the popularity of Ayurveda. Allopathic medicine, with its emphasis on scientific experimentation and modern drugs, gained favor among the educated elite. Ayurveda was often viewed as outdated and unscientific, and its practice declined significantly (Li et al. 2022).
Revival of Ayurveda (1500–present)
In the nineteenth century, there was a renewed interest in Ayurveda, thanks to the efforts of Indian nationalists and scholars. Figures like Mahatma Gandhi and Swami Vivekananda advocated for the revival of Indian traditional medicine. In the twentieth century, several Ayurvedic colleges were established, and the government began to promote Ayurvedic education and research. Today, Ayurveda is documented as a legitimate system of medicine in India in addition to is widely practiced alongside allopathic medicine. Ayurveda has an opulent and complex history that spans several millennia. Despite facing challenges and periods of decline, Ayurveda has survived and continues to thrive in India today. Its holistic methodology to health, with its emphasis on natural therapies, has made it an increasingly popular choice for those seeking alternative or complementary healthcare options (Singh and Reddy 2020).
Ideologies of Ayurveda
Ayurveda, the ancient Indian system of medicine, is founded on the belief that health is a state of balance between the mind, body, and spirit. According to Ayurveda, imbalances in these three elements can lead to disease. The fundamental principles of Ayurveda are listed in Table 2.
These principles form the foundation of Ayurvedic medicine along with guide the diagnosis, treatment, and prevention of disease. Ayurvedic practitioners practice countless techniques, comprising herbal remedies, diet, lifestyle changes, and yoga, to restore balance to the doshas and promote overall health and well-being (Pandurangi et al. 2017).
Diagnosis in Ayurveda
Ayurvedic diagnosis is a holistic process that aims to understand the root cause of an individual's imbalance and disease. It involves a comprehensive assessment of the patient's physical, mental, and emotional state, over and above their lifestyle and diet (Kataria et al. 2022). The following are key components of Ayurvedic diagnosis shown in Table 3.
Based on the information gathered from these diagnostic techniques, the Ayurvedic practitioner determines the patient's prakruti and vikruti. This information guides the appropriate selection of treatment strategies, including herbal remedies, diet, lifestyle changes, and yoga (Raynaud et al. 2021).
Treatment modalities
Ayurveda deals with an extensive range of treatment modalities to address various imbalances and diseases. These modalities aim to restore balance to the doshas, promote self-healing, and support the body's natural detoxification processes (Singh et al. 2024b). Here some significant Ayurvedic treatment modalities are: Herbal Remedies i.e., Ayurveda utilizes a vast array of herbs and herbal formulations to treat various ailments (Singh et al. 2022a, b). These herbs are believed to possess specific medicinal properties that can balance the doshas, alleviate symptoms, and promote healing. Ayurvedic herbal remedies are typically prepared using whole herbs or standardized extracts (Amegbor and Rosenberg 2020). A few medications or chemicals that have been produced from natural ingredients are included in Table 4.
Diet and nutrition
Ayurveda places prodigious prominence on diet and nutrition as a foundation for good health. Ayurvedic practitioners vouch for a sattvic diet, which is predominantly vegetarian, fresh, and wholesome. The diet is personalized to the individual's unique constitution and current state of imbalance. Specific foods and spices are recommended to poise the doshas and promote healing.
Panchakarma
It is a comprehensive detoxification and rejuvenation program that is considered the cornerstone of Ayurvedic treatment. It involves five main procedures: Nasya (nasal administration of herbal oils or powders), Vamana (therapeutic emesis), Basti (medicated enemas), virechana (therapeutic purgation), and raktamokshana (bloodletting). Panchakarma is typically conducted under the supervision of an authorized Ayurvedic practitioner.
Yoga and meditation
It’s an integral part of Ayurvedic treatment. Specific yoga postures, breathing exercises, and meditation techniques are recommended to poise the doshas, promote relaxation, and enhance overall well-being.
Ayurvedic massage
Ayurvedic massage, known as abhyanga, a therapeutic massage technique that uses herbal oils or ghee. Abhyanga is believed to improve circulation, promote relaxation, as well as balance the doshas. It can also be used to relieve muscle pain and stiffness.
Shirodhara
Shirodhara is a specialized Ayurvedic treatment that includes pouring a continuous stream of warm oil or medicated liquid onto the forehead. Shirodhara is believed to relax the mind, relieve stress and anxiety, and promote deep relaxation.
Ayurvedic facials and body treatments
Ayurvedic facials and body treatments use herbal pastes, oils, and powders to cleanse, nourish, and rejuvenate the skin. These treatments are believed to improve skin health, promote relaxation, along with balance the doshas (Evans et al. 2008; Ladas et al. 2015; Misawa et al. 2019). It’s imperative to note that Ayurvedic treatment modalities should be administered by qualified Ayurvedic practitioners who have undergone proper training and education. Ayurveda is a complete medicine system, and the selection of apposite treatment modalities depends on the individual's unique constitution, current state of imbalance, and specific health concerns (Nlooto and Naidoo 2016).
Contemporary relevance
Ayurveda, the ancient Indian medicine system, is gaining increasing recognition and relevance in contemporary healthcare due to its wide-ranging methodology for health and well-being. Here are some vital aspects highlighting the contemporary relevance of Ayurveda.
Focus on prevention and personalized care
Ayurveda emphasizes preventive healthcare and takes a holistic approach to patient care. Ayurvedic practitioners consider the individual's unique constitution, lifestyle, and environment when making treatment recommendations. This personalized approach can help identify and address imbalances before they manifest as full-blown diseases (Pushpa 2024).
Treatment for rheumatoid arthritis
Studies have demonstrated that by identifying particular Prakriti-based subgroups, Ayurvedic medicines can aid in the treatment of complex diseases, including rheumatoid arthritis. Personalized diets, lifestyle modifications, and herbal therapies are prescribed by Ayurvedic doctors based on each patient's distinct Prakriti (constitutional type) and symptoms.
Prakriti-based stratification of healthy individuals
By combining contemporary genomics with Ayurveda's Prakriti stratification techniques, the molecular and genomic underpinnings of the Dosha Prakriti idea have been discovered. Researchers discovered that healthy people with different Prakriti types (Pitta, Kapha, and Vata) had unique molecular signatures. By utilizing genomes and molecular phenotyping, this Ayurgenomics method allows for the methodical investigation of Ayurvedic principles.
Integration with modern medicine
Ayurveda is increasingly being integrated with modern medicine to provide an inclusive approach to healthcare. Ayurvedic principles and practices are being studied and incorporated into mainstream medical care, particularly in areas such as chronic diseases, stress management, and mental health (Sharma and Prajapati 2020).
The conflict between the traditional way of Ayurveda and the modern medical practice
The ancient Ayurvedic approach and contemporary medical treatment disagree on a number of important points: Lack of Standardization: Ayurvedic medications are created using natural components, which can vary in quality and potency, resulting to inconsistent effectiveness. This is in contrast to modern medicine, where drugs are synthesized in a lab under tight restrictions. Standard Operating Procedures (SOPs) versus Customization: Ayurvedic clinical practice is centered around customization, whereas modern medicine requires standard operating procedures (SOPs). A significant disagreement arises between the two systems as a result (Singh et al. 2024c). Evidence-based Practice: The majority of Ayurvedic treatments lack rigorous scientific study and evidence-based validation, which makes it challenging for Ayurveda to be incorporated into mainstream medicine. Integration Challenges: Lack of trust, technical incompatibilities, difficulties with operational coordination, and regulatory obstacles are some of the obstacles that stand in the way of integrating Ayurveda with contemporary medicine. Reductionist Approach: Ayurveda treats the patient holistically, whereas modern medicine takes a reductionist approach. When creating an interface between Ayurveda and modern medicine, caution must be taken to avoid unduly reductionist treatment of Ayurveda. Safety Myths: People frequently believe that Ayurvedic medications are safe and have no adverse effects, which can result in self-medication and even injury. It is essential for the successful integration of Ayurveda and contemporary medicine to resolve these tensions through standardization, evidence-based research, and a cooperative approach in order to deliver safe and efficient patient treatment (Chopra and Doiphode 2002).
Scientific research and validation
An emergent body of scientific research supports the efficacy of Ayurvedic herbs, therapies, and formulations. Clinical studies have demonstrated the effectiveness of Ayurveda in managing various conditions, including arthritis, diabetes, hypertension, and anxiety (Gupta 2024).
Integrative and complementary medicine
Ayurveda is gaining acceptance as a integrative and complementary medicine system that can be used alongside conventional medicine to enhance treatment outcomes and improve overall well-being (Olbara et al. 2018). Table 5 Ayurvedic therapies can help reduce the conventional treatments' side effects and promote a faster recovery.
Lifestyle and wellness
Ayurvedic principles and practices, for instance, meditation, yoga, and a sattvic diet, are becoming popular in modern lifestyle and wellness trends. These practices are recognized for their ability to promote mental and physical well-being, diminish stress as well as enhance overall quality of life (Palileo-Villanueva et al. 2022).
Herbal medicine and nutraceuticals
Ayurvedic herbs and formulations are increasingly being used as nutraceuticals and dietary supplements to support complete health and well-being Table 6. The demand for standardized Ayurvedic herbal extracts and formulations is growing globally.
An organized display of medicinal plants, their corresponding products, potential interactions between drugs and herbs, and an analysis of their effectiveness is shown in Fig. 3.
Ayurvedic spas and wellness retreats
Ayurvedic spas and wellness retreats are becoming popular destinations for individuals seeking rejuvenation, relaxation, and healing. These retreats offer a range of Ayurvedic therapies, treatments, and lifestyle interventions to promote mental, emotional, and physical well-being (Peltzer and Pengpid 2019).
The challenge of standardizing Ayurvedic practice
Creating integrative treatment guidelines based on evidence could be one way to solve the issue of standardization in Ayurveda. The integration of contemporary scientific research methodology with Ayurvedic principles may facilitate the development of standardized yet customized treatment regimens that capitalize on the advantages of both systems. This may entail locating essential Ayurvedic medicines, formulas, and techniques that have shown effective in clinical trials and incorporating them into all-encompassing, patient-focused treatment plans. Furthermore, putting in place regulatory frameworks and quality control procedures for Ayurvedic treatments and products could help guarantee consistency and safety, opening the door for Ayurveda to be more widely accepted and integrated into mainstream healthcare. Even though there are still difficulties, this integrated method may offer more concrete answers that close the knowledge gap between conventional medicine and Ayurvedic medicine.
Challenges associated with the use of AYUSH
When applied to modern medicine, Ayurveda, Yoga, Unani, Siddha, and Homoeopathy (AYUSH) presents several challenges: Absence of Scientific Confirmation Scientists haven't looked into the effectiveness of many AYUSH therapies in great detail, and the evidence for this is weak. The marketing of Ayurvedic procedures and items in the West has led to cultural appropriation and the loss of integrity and cultural identity. Safety and Quality Control Issues: There are concerns regarding the safety and quality of Ayurvedic products because they are not governed by many countries. Various goods have been found to contain hazardous compounds, such as heavy metals.
Integration with Modern Medicine: The primary barriers to the integration of AYUSH with modern medication are a lack of solid scientific research and the need for evidence-based validation. Misconceptions and Self-Medication: The common misconception that AYUSH drugs have no side effects may lead to self-medication and potential harm. Challenges with Education and Regulation: AYUSH practice and education are not subject to the same stringent standards and regulations as modern medicine, which makes it challenging to ensure the efficacy as well as safety of AYUSH therapies. The security and efficacy of herbal treatments While Ayurvedic medicines have long been considered safe, their effectiveness is sometimes only moderate, thus further research is needed to find out how efficient they are in treating certain conditions. These problems must be fixed in order to ensure the efficacy and safety of AYUSH treatments and to facilitate the seamless integration of AYUSH with modern medicine (Chandola 2012; Ghate and Wele 2022).
Global acknowledgement and acceptance
Ayurveda’s growing recognition and acceptance worldwide as a legitimate system of medicine. Several countries have incorporated Ayurveda into their national healthcare systems, and Ayurvedic practitioners are increasingly being recognized as healthcare professionals. Overall, Ayurveda's contemporary relevance lies in its holistic approach toward health, its focus on prevention and personalized care, and its growing scientific validation. The amalgamation of modern medicine with Ayurveda and its increasing popularity in lifestyle and wellness trends further contribute to its relevance in the twenty-first century (Kumar et al. 2022a; Peltzer et al. 2008; Ramakrishnan et al. 2014).
Conclusions
Ayurveda, the ancient Indian system of medicine, has a rich and complex history spanning over several millennia. Its principles and practices are established on the credence that health is a state of balance between the mind, body, and spirit. Ayurveda emphasizes prevention and personalized care, besides the natural therapies use to promote healing and well-being. Despite its long history and contributions to healthcare, Ayurveda faced challenges and periods of decline, particularly during the colonial era. However, in recent decades, there has been a renewed interest in Ayurveda, both in India and globally. This revival is driven by several factors. There is growing recognition of the limitations of conventional medicine in addressing chronic diseases and lifestyle-related disorders—increased awareness of the holistic and preventive approach of Ayurveda. Scientific research supporting the safety and efficacy of Ayurvedic herbs and therapies. Integration of Ayurveda with modern medicine and healthcare systems. Ayurveda's contemporary relevance lies in its focus on personalized care, its emphasis on prevention and lifestyle management, and its potential role in addressing chronic diseases and promoting mental and emotional well-being. The amalgamation of Ayurveda with modern medicine and the growing body of scientific research supporting its efficacy is further contributing to its acceptance and recognition worldwide. As we move forward, it’s crucial to continue to study and validate Ayurvedic principles and practices through rigorous scientific research. This will help to establish Ayurveda as a credible and evidence-based system of medicine, further enhancing its relevance and integration into modern healthcare systems. In summary, Ayurveda, with its rich history, holistic approach, and growing scientific validation, is a valuable resource for promoting health and well-being in the twenty-first century. Its principles and practices can complement and enhance conventional medicine, providing individuals with a wide-ranging and personalized methodology for healthcare.
Availability of data and materials
Not applicable.
Abbreviations
- AYUSH:
-
Ayurveda, Yoga, Unani, Siddha, and Homeopathy
- BCE:
-
Before the Common Era
References
Abbi C, Kumar V, Kumar S, Kumar D (2013) Punarnava (Boerhavia diffusa): a promising indigenous herbal drug. Int Res J Pharm 4:85–89. https://doi.org/10.7897/2230-8407.04314
Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Sarfaraz RA, Shah A, Kandhro GA, Shah AQ, Baig JA (2008) Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. Biol Trace Elem Res 124(3):206–224. https://doi.org/10.1007/s12011-008-8142-7
Agarwal S, Gupta SJ, Saxena AK, Gupta N, Agarwal S (2010) Urolithic property of Varuna (Crataeva nurvala): an experimental study. AYU 31(3):361–366. https://doi.org/10.4103/0974-8520.77161
Ahmad S, Zahiruddin S, Parveen B, Basist P, Parveen A, Gaurav, Parveen R, Ahmad M (2021) Indian medicinal plants and formulations and their potential against COVID-19–preclinical and clinical research. Front Pharmacol. https://doi.org/10.3389/fphar.2020.578970
Al Mahmud A, Siddiqui SA, Karim MR, Al-Mamun MR, Akhter S, Sohel M, Hasan M, Bellah SF, Amin MN (2023) Clinically proven natural products, vitamins and mineral in boosting up immunity: a comprehensive review. Heliyon 9(4):e15292. https://doi.org/10.1016/j.heliyon.2023.e15292
Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M (2013) Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): a review. Asian Pac J Trop Dis 3(3):242–251. https://doi.org/10.1016/S2222-1808(13)60049-3
Amalraj A, Karthik Varma AC, Jude S, Kuttappan S (2022) Ginger in ayurvedic preparations and its applications in the development of nutraceuticals, dietary supplements and functional foods and their beneficial effects in various biological activities. https://doi.org/10.1039/9781839166211-00045
Amegbor PM, Rosenberg MW (2020) Predictors of unmet traditional, complementary and alternative medicine need among persons of sub-saharan african origin living in the Greater Toronto area. J Immigr Minor Health 22(5):1031–1038. https://doi.org/10.1007/s10903-020-01003-8
Ansari A, Mahmood T, Bagga P, Ahsan F, Shamim A, Ahmad S, Shariq M, Parveen S (2021) Areca catechu: a phytopharmacological legwork. Food Front 2(2):163–183. https://doi.org/10.1002/fft2.70
Ayabe S, Takano H, Fujita T, Furuya T, Hirota H, Takahashi T (1990) Triterpenoid biosynthesis in tissue cultures of Glycyrrhiza glabra var. Glandulifera. Plant Cell Rep. https://doi.org/10.1007/BF00232175
Azharhusain S, Shrivastava B, Quazi A, Arshad M, Shaikh J, Patwekar M (2022) A review on guggulu [Commiphora wightii (arn.) bhand.], its phytochemical constitution & mode of action. Int J Ayurveda Pharma Res 10:74. https://doi.org/10.47070/ijapr.v10i5.2298
Babalola OO, Adedayo AA (2023) Endosphere microbial communities and plant nutrient acquisition toward sustainable agriculture. Emerg Top Life Sci 7(2):207–217. https://doi.org/10.1042/ETLS20230069
Bagade A, Tripathi VD, Charde M, Rane A, Narkhede S (2023) Phytochemical evaluation of Bharangi (Clerodendrum serratum linn) roots under Konkan condition. Int J Farm Sci 13:93–97. https://doi.org/10.5958/2250-0499.2023.00018.6
Baliga MS, Shivashankara AR, Thilakchand KR, Baliga-Rao MP, Palatty PL, George T, Rao S (2019) Hepatoprotective effects of the Indian gooseberry (Emblica officinalis Gaertn). In: Watson RR, Preedy VR (eds) Dietary interventions in liver disease. Academic Press, New York, pp 193–201. https://doi.org/10.1016/B978-0-12-814466-4.00016-1
Bao XQ, Liu GT (2008) Bicyclol: a novel antihepatitis drug with hepatic heat shock protein 27/70-inducing activity and cytoprotective effects in mice. Cell Stress Chaperones 13(3):347–355. https://doi.org/10.1007/s12192-008-0034-4
Bhinde SM, Bhinde SS, Kori VK, Patel KS (2020) A compendious review of Chitraka Haritaki Avaleha—a polyherbal Ayurveda formulation for bronchial asthma. AYU 41(1):12–18. https://doi.org/10.4103/ayu.AYU_340_20
Bourque S, Binet M-N, Ponchet M, Pugin A, Lebrun-Garcia A (1999) Characterization of the cryptogein binding sites on plant plasma membranes*. J Biol Chem 274(49):34699–34705. https://doi.org/10.1074/jbc.274.49.34699
Caldwell MM, Bornman JF, Ballaré CL, Flint SD, Kulandaivelu G (2007) Terrestrial ecosystems, increased solar ultraviolet radiation, and interactions with other climate change factors. Photochem Photobiol Sci 6(3):252–266. https://doi.org/10.1039/B700019G
Chandola HM (2012) New challenges for Ayurveda: how it will stand? AYU 33(2):165–166. https://doi.org/10.4103/0974-8520.105231
Chauhan D, Singh D, Pandey H, Khan Z, Srivastava R, Dhiman VK, Dhiman VK (2023) Impact of transcription factors in plant abiotic stress: a recent advancement for crop improvement. In: Srivastava V et al (eds) Plant transcription factors. Elsevier, Amsterdam, pp 271–286. https://doi.org/10.1016/B978-0-323-90613-5.00005-4
Chopra A, Phode VV (2002) Ayurvedic medicine. Core concept, therapeutic principles, and current relevance. Med Clin N Am 86(1):75–89. https://doi.org/10.1016/s0025-7125(03)00073-7
Choudhary S, Chaudhary G, Kaurav H (2021a) Aegle marmelos (bael patra): an ayurvedic plant with ethnomedicinal value. Int J Res Ayurveda Pharm 12:147–156. https://doi.org/10.7897/2277-4343.120392
Choudhary S, Kumari I, Thakur S, Kaurav H, Chaudhary G (2021b) Brahmi (Bacopa monnieri): a potential ayurvedic cognitive enhancer and neuroprotective herb. Int J Ayurveda Pharma Res. https://doi.org/10.47070/ijapr.v9i5.1917
Cohen MM (2014) Tulsi—Ocimum sanctum: a herb for all reasons. J Ayurveda Integr Med 5(4):251–259. https://doi.org/10.4103/0975-9476.146554
De Santo AV, Bartoli G, Alfani A, Ianni M (1979) Responses of Mentha piperita L. and Arabidopsis thaliana L. to fumigation with SO2 at different concentrations. J Environ Sci Health Part A Environ Sci Eng 14(4):313–332. https://doi.org/10.1080/10934527909374881
Deogade M (2016) Literature review of palash (Butea monosperma Lamk. Taub). Int Ayurvedic Med J 1:101–106
Devendra S (2021) Herbal antibacterial remedy against upper respiratory infection causing bacteria and in vivo safety analysis. Vegetos 35(1):264–268
Devendra S, Vishnu A (2021) A review on the COVID-19, its history, diagnostic approaches, role of herbs and current world scenario. Biomedicine 41(2):328–332. https://doi.org/10.51248/.v41i2.1032
Dey YN, Ota S, Srikanth N, Jamal M, Wanjari M (2012) A phytopharmacological review on an important medicinal plant—Amorphophallus paeoniifolius. AYU 33(1):27–32. https://doi.org/10.4103/0974-8520.100303
Dwivedi S, Dubey R, Mehta K (2008) Achyranthes aspera Linn. (Chirchira): a magic herb in folk medicine. Ethnobot Leafl 12:89
Evans A, Duncan B, McHugh P, Shaw J, Wilson C (2008) Inpatients’ use, understanding, and attitudes towards traditional, complementary and alternative therapies at a provincial New Zealand hospital. N Z Med J 121(1278):21–34
Fahamiya N, Shiffa M, Miriyalilini P (2018) Kulanjan (Alpinia galanga) from the perspective of unani medicine. Int J Sci Innov Discov 5:2319–8141
Gantait S, Panigrahi J (2018) In vitro biotechnological advancements in Malabar nut (Adhatoda vasica Nees): achievements, status and prospects. J Genet Eng Biotechnol 16(2):545–552. https://doi.org/10.1016/j.jgeb.2018.03.007
Gao J, Ajala OS, Wang C-Y, Xu H-Y, Yao J-H, Zhang H-P, Jukov A, Ma C-M (2016) Comparison of pharmacokinetic profiles of Terminalia phenolics after intragastric administration of the aqueous extracts of the fruit of Terminalia chebula and a Mongolian compound medicine-Gurigumu-7. J Ethnopharmacol 185:300–309. https://doi.org/10.1016/j.jep.2016.03.016
Gaonkar VP, Hullatti K (2020) Indian traditional medicinal plants as a source of potent anti-diabetic agents: a review. J Diabetes Metab Disord 19(2):1895–1908. https://doi.org/10.1007/s40200-020-00628-8
Ghate U, Wele A (2022) Globalization of AYUSH products: status, challenges and suggestions for growth. Folklore 1:21–34
Gholap S, Kar A (2003) Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 58(6):413–415
Godaly G, Ambite I, Puthia M, Nadeem A, Ho J, Nagy K, Huang Y, Rydström G, Svanborg C (2016) Urinary tract infection molecular mechanisms and clinical translation. Pathogens. https://doi.org/10.3390/pathogens5010024
Gohil KJ, Patel JA, Gajjar AK (2010) Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharm Sci 72(5):546–556. https://doi.org/10.4103/0250-474X.78519
Gupta R (2024) Integrating Ayurveda with modern medicine for enhanced patient care: analysis of realities. The Physician 9:1–6. https://doi.org/10.38192/1.9.1.3
Gupta R, Doss R, Lall R, Sinha A, Srivastava A, Malik J (2019) Babool (Acacia nilotica). Springer, Cham, pp 103–111. https://doi.org/10.1007/978-3-030-04624-8_8
Gupta RC, Kalidindi SR, Doss RB, Lall R, Srivastava A, Sinha A (2021) Chapter 14—nutraceuticals in arthritis. In: Gupta RC, Lall R, Srivastava A (eds) Nutraceuticals, 2nd edn. Academic Press, New York, pp 193–214. https://doi.org/10.1016/B978-0-12-821038-3.00014-8
Holmes FA, Walters RS, Theriault RL, Forman AD, Newton LK, Raber MN, Buzdar AU, Frye DK, Hortobagyi GN (1991) Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 83(24):1797–1805. https://doi.org/10.1093/jnci/83.24.1797-a
Honwad S (2017) Origin & development of Ayurveda
Hossain M (2015) Nutritional value and medicinal benefits of pineapple. Int J Nutr Food Sci 4:84. https://doi.org/10.11648/j.ijnfs.20150401.22
Ibáñez B, Melero A, Montoro A, Merino-Torres JF, Soriano JM, San Onofre N (2023) A narrative review of the herbal preparation of Ayurvedic, traditional Chinese, and Kampō medicines applied as radioprotectors. Antioxidants 12(7):1437. https://doi.org/10.3390/antiox12071437
Imam H, Lone A, Seikh A, Sofi G, Nigar Z (2014) The incredible benefits of Nagarmotha (Cyperus rotundus). Int J Nutr Pharmacol Neurol Dis 4:23. https://doi.org/10.4103/2231-0738.124611
Jain AK (2016) Indian ethnobotany: emerging trends. Scientific Publishers, Jodhpur
Jaiswal YS, Williams LL (2016) A glimpse of Ayurveda: the forgotten history and principles of Indian traditional medicine. J Tradit Complement Med 7(1):50–53. https://doi.org/10.1016/j.jtcme.2016.02.002
Joshi A, Kalauni D, Bhattarai S (2019) Survey on usage of medicinal plants: a case from Chitwan district of Nepal. SAARC J. Agric 16:129–141. https://doi.org/10.3329/sja.v16i2.40265
Joshi VK, Joshi A, Joshi VK, Joshi A (2021) Garlic in traditional Indian medicine (Ayurveda) for health and healing. In: Ahmad RS (ed) Herbs and spices—new processing technologies. IntechOpen, London. https://doi.org/10.5772/intechopen.97495
Kakodkar P, Sharma R, Dubewar AP (2021) Classical vs commercial: Is the “efficacy” of chyawanprash lost when tradition is replaced by modernization? J Ayurveda Integr Med 12(4):751–752. https://doi.org/10.1016/j.jaim.2021.08.014
Kalam M, Khanday S, Salim S, Ahmad A (2019) Malkangni (Celastrus paniculatus Willd.): neuropharmacological properties in perspective of unani medicine and pharmacological studies-a review. World J Pharm Pharm Sci 08:381–391. https://doi.org/10.20959/wjpps20192-13113
Kamal N, Ilowefah MA, Hilles AR, Anua NA, Awin T, Alshwyeh HA, Aldosary SK, Jambocus NGS, Alosaimi AA, Rahman A, Mahmood S, Mediani A (2022) Genesis and mechanism of some cancer types and an overview on the role of diet and nutrition in cancer prevention. Molecules (basel, Switzerland) 27(6):1794. https://doi.org/10.3390/molecules27061794
Kareem A, Govindharaj Y, Sunkara J (2022) An evaluation of Indian Ayurvedic medicinal plants. Int J Emerg Res Eng Sci Manag 1:14–18. https://doi.org/10.58482/ijeresm.v1i3.4
Kataria S, Sharma P, Ram JP, Deswal V, Singh M, Rana R, Singhal R, Tripathi A, Kumar K, Trehan N (2022) A pilot clinical study of an add-on Ayurvedic formulation containing Tinospora cordifolia and Piper longum in mild to moderate COVID-19. J Ayurveda Integr Med 13(2):100454. https://doi.org/10.1016/j.jaim.2021.05.008
Kimothi GP (2016) Akarkarabh: an important medicinal herb. Info-Ayurveda 12:16–19
Končić MZ (2017) 7—role of selected medicinal plants in sports nutrition and energy homeostasis. In: Bagchi D (ed) Sustained energy for enhanced human functions and activity. Academic Press, New York, pp 119–135. https://doi.org/10.1016/B978-0-12-805413-0.00007-7
Korikanthimathm V, Prasath D, Rao G (2001) Medicinal properties of Elettaria cardamomum. J Med Aromat Plant Sci 22:683–685
Krunal A, Doshi K (2015) “Kumari (Aloe vera Tourn. ex Linn.)” a miraculous herb on the earth: a classical review. Int J Ayurvedic Herb Med 5:3–2015
Kumar P, Rai S, Verma SK, Prakash PS, Chitara D (2022a) Classification, mode of action and uses of various immunomodulators. In: Kesharwani RK, Keservani RK, Sharma AK (eds) Immunomodulators and human health. Springer, Singapore, pp 3–38. https://doi.org/10.1007/978-981-16-6379-6_1
Kumar P, Verma SK, Rai S, Prakash PS, Chitara D (2022b) Role of homocysteine metabolism in cardiovascular diseases. In: Dubey GP, Misra K, Kesharwani RK, Ojha RP (eds) Homocysteine metabolism in health and disease. Springer, Singapore, pp 257–276. https://doi.org/10.1007/978-981-16-6867-8_14
Ladas EJ, Lin M, Antillion F, Rivas S, Chantada G, Cacciavillano W, Ortiz R, Stein K, Castillo L, Rocha V, Fu L, Rodriquez H, Kelly KM (2015) Improving our understanding of the use of traditional complementary/alternative medicine in children with cancer. Cancer 121(9):1492–1498. https://doi.org/10.1002/cncr.29212
Li M, Liu G-T (2004) Inhibition of Fas/FasL mRNA expression and TNF-alpha release in concanavalin A-induced liver injury in mice by bicyclol. World J Gastroenterol 10(12):1775–1779. https://doi.org/10.3748/wjg.v10.i12.1775
Li XL, Wu L, Wang Z (2022) A brief introduction of Ayurvedic medical classics. Zhonghua Yi Shi Za Zhi (beijing, China: 1980) 52(1):33–40. https://doi.org/10.3760/cma.j.cn112155-20210423-00059
Liu Y, Wang W, Sun M, Ma B, Pang L, Du Y, Dong X, Yin X, Ni J (2019) Polygonum multiflorum-induced liver injury: clinical characteristics, risk factors, material basis, action mechanism and current challenges. Front Pharmacol. https://doi.org/10.3389/fphar.2019.01467
Lohiya NK, Balasubramanian K, Ansari AS (2016) Indian folklore medicine in managing men’s health and wellness. Andrologia 48(8):894–907. https://doi.org/10.1111/and.12680
Madgundi A, Nitin C, Chaudhari M, Chaudhari Y (2023) Amaltas (Cassia fistula linn.)—a medicinal and pharmaceutical plant. Int J Ayurvedic Med 14:341–345. https://doi.org/10.47552/ijam.v14i2.3405
Mathai RT, Tonse R, Kalekhan F, Colin MD, Prabhu HS, Rao S, Baliga MS (2015) Chapter 3: amla in the prevention of aging: scientific validation of the ethnomedicinal claims. In: Watson RR (ed) Foods and dietary supplements in the prevention and treatment of disease in older adults. Academic Press, New York, pp 29–35. https://doi.org/10.1016/B978-0-12-418680-4.00003-8
Mirunalini S, Krishnaveni M (2010) Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharmacol 21(1):93–105. https://doi.org/10.1515/JBCPP.2010.21.1.93
Misawa J, Ichikawa R, Shibuya A, Maeda Y, Arai I, Hishiki T, Kondo Y (2019) The impact of uncertainty in society on the use of traditional, complementary and alternative medicine: a comparative study on visits to alternative/traditional/folk health care practitioners. BMC Complement Altern Med 19(1):251. https://doi.org/10.1186/s12906-019-2662-x
Mishra A, Vijayaraghavalu S, Kumar M (2022) 24—cardiovascular disorders and herbal medicines in India. In: Sarwat M, Siddique H (eds) Herbal medicines. Academic Press, New York, pp 525–555. https://doi.org/10.1016/B978-0-323-90572-5.00005-6
Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul A, Devasagayam T (2007) Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 40(3):163–173. https://doi.org/10.3164/jcbn.40.163
Mukherjee P, Senapati S, Mandal D, Ahmad A, Khan MI, Kumar R, Sastry M (2002) Extracellular synthesis of gold nanoparticles by the fungus Fusarium oxysporum. ChemBioChem 3(5):461. https://doi.org/10.1002/1439-7633(20020503)3:5%3c461::AID-CBIC461%3e3.0.CO;2-X
Muskal SM, Sliman J, Kokai-Kun J, Pimentel M, Wacher V, Gottlieb K (2016) Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway. F1000Research 5:606. https://doi.org/10.12688/f1000research.8406.3
Nair A, Chattopadhyay D, Saha B (2019) Chapter 17: plant-derived immunomodulators. In: Ahmad Khan MS, Ahmad I, Chattopadhyay D (eds) New look to phytomedicine. Academic Press, New York, pp 435–499. https://doi.org/10.1016/B978-0-12-814619-4.00018-5
Narayana DBA, Durg S (2021) Ayurveda: (W)here is the evidence. J Ayurveda Integr Med 12(2):408–411. https://doi.org/10.1016/j.jaim.2020.07.001
Nlooto M, Naidoo P (2016) Traditional, complementary and alternative medicine use by HIV patients a decade after public sector antiretroviral therapy roll out in South Africa: a cross sectional study. BMC Complement Altern Med 16:128. https://doi.org/10.1186/s12906-016-1101-5
Nyeem M (2017) Ashoka (Saraca indica) as women friendly plant: a review. Natl J Adv Res 3:03–07
Olbara G, Parigger J, Njuguna F, Skiles J, Sitaresmi MN, Gordijn S, van de Ven P, Kaspers G, Mostert S (2018) Health-care providers’ perspectives on traditional and complementary alternative medicine of childhood cancer in Kenya. Pediatr Blood Cancer 65(12):e27309. https://doi.org/10.1002/pbc.27309
Palileo-Villanueva LM, Palafox B, Amit AML, Pepito VCF, Ab-Majid F, Ariffin F, Balabanova D, Isa M-R, Mat-Nasir N, My M, Renedo A, Seguin ML, Yusoff K, Dans AL, Mckee M (2022) Prevalence, determinants and outcomes of traditional, complementary and alternative medicine use for hypertension among low-income households in Malaysia and the Philippines. BMC Complement Med Ther 22(1):252. https://doi.org/10.1186/s12906-022-03730-x
Pandey MM, Rastogi S, Rawat AKS (2013) Indian traditional ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Altern Med Ecam 2013:376327. https://doi.org/10.1155/2013/376327
Pandurangi AK, Keshavan MS, Ganapathy V, Gangadhar BN (2017) Yoga: past and present. Am J Psychiatry 174(1):16–17. https://doi.org/10.1176/appi.ajp.2016.16080853
Parmar N, Singh S, Patel B (2016) Various pathya kalpana of Bilva [Aegle marmelos (L.) Correa ex Roxb.]: a review. Glob J Res Med Plants Indig Med 5:57–78
Pathak M, Vyas H, Vyas MK (2010) A clinical trial of Pippali (Piper longum Linn.) with special reference to Abheshaja. AYU 31(4):442–446. https://doi.org/10.4103/0974-8520.82038
Pathak AK, Singh V, Pal M, Mishra T, Goel K, Gupta VS (2017) Evaluation of topical application of Vajradanti gel in prevention of gingivitis. Open J Stomatol 07(02):105–112. https://doi.org/10.4236/ojst.2017.72006
Paul S, Chakraborty S, Anand U, Dey S, Nandy S, Ghorai M, Saha SC, Patil MT, Kandimalla R, Proćków J, Dey A (2021) Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomed Pharmacother 143:112175. https://doi.org/10.1016/j.biopha.2021.112175
Peltzer K, Pengpid S (2019) A survey of the training of traditional, complementary, and alternative medicine in universities in Thailand. J Multidiscip Healthc 12:119–124. https://doi.org/10.2147/JMDH.S189644
Peltzer K, Preez NF, Ramlagan S, Fomundam H (2008) Use of traditional complementary and alternative medicine for HIV patients in KwaZulu-Natal, South Africa. BMC Public Health 8:255. https://doi.org/10.1186/1471-2458-8-255
Piermaria JA, Pinotti A, Garcia MA, Abraham AG (2009) Films based on kefiran, an exopolysaccharide obtained from kefir grain: development and characterization. Food Hydrocoll 23(3):684–690. https://doi.org/10.1016/j.foodhyd.2008.05.003
Priyanka, Tiwari R, Yadav A, Sharma A, Indermani (2023) Medicinal uses of poisonous plant—a brief review. Int J Ayurveda Pharma Res 48:51. https://doi.org/10.47070/ijapr.v10i12.2614
Pundarikakshudu K, Patel MG, Shah PA (2024) Chapter 2: an overview of some Indian vegetables, fruits, and spices effective in diabetes and metabolic disorders—current status and future scenarios. In: Naeem M, Aftab T (eds) Antidiabetic medicinal plants. Academic Press, New York, pp 75–139. https://doi.org/10.1016/B978-0-323-95719-9.00004-5
Pushpa D (2024) The personalized approach of prevention and curing disease: the Ayurvedic way towards symbiohealth-Need of the hour Program I think expect to discuss about ….
Ram S, Kotecha M, Joshi K (2021a) Review on Abutilon Indicum (Linn). Sweet (Atibala): an important herb in Ayurveda. Int Res J Ayurveda Yoga 4:172–178. https://doi.org/10.47223/IRJAY.2021.4823
Ram S, Sharma R, Kotecha M, Joshi K (2021b) Preliminary pharmacognosy evaluation of The Bark of Acacia catechu (Wild.). Int Res J Ayurveda Yoga. https://doi.org/10.47223/IRJAY.2021.4420
Ramakrishnan P, Rane A, Dias A, Bhat J, Shukla A, Lakshmi S, Ansari BK, Ramaswamy RS, Reddy RA, Tribulato A, Agarwal AK, SatyaPrasad N, Mushtaq A, Rao PH, Murthy P, Koenig HG (2014) Indian health care professionals’ attitude towards spiritual healing and its role in alleviating stigma of psychiatric services. J Relig Health 53(6):1800–1814. https://doi.org/10.1007/s10943-014-9822-6
Rangasamy I, Roshy JC (2010) Hepatoprotective and hepatocurative activity of the traditional medicine ketaki (Pandanus odoratissimus Roxb.)—an experimental evaluation. Asian J Tradit Med 5:212–218
Raynaud M, Zhang H, Louis K, Goutaudier V, Wang J, Dubourg Q, Wei Y, Demir Z, Debiais C, Aubert O, Bouatou Y, Lefaucheur C, Jabre P, Liu L, Wang C, Jouven X, Reese P, Empana J-P, Loupy A (2021) COVID-19-related medical research: a meta-research and critical appraisal. BMC Med Res Methodol 21(1):1. https://doi.org/10.1186/s12874-020-01190-w
Reddy IVS, Palagani N (2022) Neem (Azadirachta indica): a review on medicinal Kalpavriksha. Int J Econ Plants. https://doi.org/10.23910/2/2021.0437d
Sabharwal S, Anand N, Kaur S, Mehta M, Singh S (2021) An overview on Kalamegha (Andrographis paniculata). Asian Pac J Health Sci 8:57–65. https://doi.org/10.21276/apjhs.2021.8.4S.10
Samy RP, Pushparaj PN, Gopalakrishnakone P (2008) A compilation of bioactive compounds from Ayurveda. Bioinformation 3(3):100–110
Sarvade D, Kamini B, Mohanlal J (2018) The queen of spices and ayurveda: a brief review. Int J Res Ayurveda Pharm. https://doi.org/10.7897/2277-4343.075207
Semwal DK, Chauhan A, Kumar A, Aswal S, Semwal RB, Kumar A (2019) Status of Indian medicinal plants in the International Union for Conservation of Nature and the future of Ayurvedic drugs: shouldn’t think about Ayurvedic fundamentals? J Integr Med 17(4):238–243. https://doi.org/10.1016/j.joim.2019.04.008
Shah S (2019) Ayurveda: the conventional Indian medicine system and its global practice. Int J Innov Sci Technol. https://doi.org/10.22270/ijist.v4i1.36
Shakyawal S, Mahobiya D (2023) Glycyrrhiza Glabra (Mulethi) A Boon in Ayurveda: a review. J Nat Ayurvedic Med. https://doi.org/10.23880/jonam-16000405
Sharma R, Prajapati P (2020) Predictive, preventive and personalized medicine: leads from ayurvedic concept of Prakriti (human constitution). Curr Pharmacol Rep. https://doi.org/10.1007/s40495-020-00244-3
Sharma SK, Singh D, Pandey H, Jatav RB, Singh V, Pandey D (2022) An overview of roles of enzymatic and nonenzymatic antioxidants in plant. In: Aftab T, Hakeem KR (eds) Antioxidant defense in plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-7981-0_1
Shi Y, Zhang C, Li X (2021) Traditional medicine in India. J Tradit Chin Med Sci 8:S51–S55. https://doi.org/10.1016/j.jtcms.2020.06.007
Shyamlal YS, Jaiswal M, Prajapati PK (2012) Therapeutic potentials of Shirisha (Albizia lebbeck Benth): a review. Int J Ayurvedic Med 2:4. https://doi.org/10.47552/ijam.v2i4.72
Singh D, Agarwal V (2021) Screening of antimicrobial, anti-quorum sensing activity and cytotoxicity of origanum oil against Gram-positive and Gram-negative bacteria. Biomedicine 41(3):599–603
Singh D, Agarwal V (2022) Herbal antibacterial remedy against upper respiratory infection causing bacteria and in vivo safety analysis. Vegetos 35:264–268. https://doi.org/10.1007/s42535-021-00281-3
Singh D, Agarwal V (2023) An in vivo acute toxicity and anti-shigellosis effect of designed formulation on rat. J Ayurveda Integr Med 14(1):100536
Singh C, Reddy DT (2020) Yoga origin, history and development in India. Indian J Mov Educ Exerc Sci 8:9–12
Singh S, Parmar N, Patel B (2015) A review on Shalparni (Desmodium gangeticum DC.) and Desmodium species (Desmodium triflorum DC. & Desmodium laxiflorum DC.): ethnomedicinal perspectives. J Med Plants Stud 38:38–43
Singh D, Sharma D, Agarwal V (2021) Screening of anti-microbial, anti-biofilm activity, and cytotoxicity analysis of a designed polyherbal formulation against shigellosis. J Ayurveda Integr Med 12(4):601–606
Singh A, Gautam A, Singh B, Navneet (2022a) Chapter 2—antiviral effects of medicinal plants and their active phytochemical constituents against respiratory diseases and associated biological functions. In: Egbuna C (ed) Coronavirus drug discovery. Elsevier, Amsterdam, pp 23–54. https://doi.org/10.1016/B978-0-323-95574-4.00012-3
Singh D, Singh V, Mishra SB, Sharma D, Agarwal V (2022b) Evaluation of anti-biofilm, anti-quorum, anti-dysenteric potential of designed polyherbal formulation: in vitro and in vivo study. J Appl Biomed 20(1):7–14
Singh D, Sharma A, Verma SK, Pandey H, Pandey M (2024a) Impact of nanoparticles on plant physiology, nutrition, and toxicity: a short review. Next Nanotechnol 6:100081. https://doi.org/10.1016/j.nxnano.2024.100081
Singh D, Verma SK, Shyam P (2024b) Identification and purification of plant secondary metabolite as medicinal raw materials. In: Kuma A, Kumar S (eds) Secondary metabolites and biotherapeutics. Elsevier, Amsterdam, pp 9–38. https://doi.org/10.1016/B978-0-443-16158-2.00003-3
Singh D, Verma SK, Wani KI, Aftab T (2024c) An overview of metal and metalloid toxicity and signaling in plants. In: Aftab T (ed) Metals and metalloids in plant signaling. Springer, Cham, pp 1–17. https://doi.org/10.1007/978-3-031-59024-5_1
Singh V, Pandey H, Misra V, Singh D (2022c) Biocompatible herbal polymeric nanoformulation of [6]-Gingerol: development, optimization, and characterization. Ecol Environ Conserv 28(3):372–376
Singh D, Pandey H, Singh V (2022d) Natural products that target cancer stem cells. In: Pandurangan A, Anandasadagopan S, Alhumaydhi F (eds) Handbook of research on natural products and their bioactive compounds as cancer therapeutics. IGI Global, Hershey, pp 169–186. https://doi.org/10.4018/978-1-7998-9258-8.ch008
Singh D et al. (2022e) Secondary metabolite engineering for plant immunity against various pathogens. In: Aftab T, Hakeem KR (eds) Metabolic engineering in plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-7262-0_5
Srivastava B, Sharma H, Dey Y, Wanjari M, Jadhav A (2014) Alhagi pseudalhagi: a review of its phyto-chemistry, pharmacology, folklore claims and Ayurvedic studies. Int J Herb Med 2:47–51
Sun H, Yu L, Wei H, Liu G (2012) A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. J Biomed Biotechnol 2012:584728. https://doi.org/10.1155/2012/584728
Suneela D (2019) An update on pharmacological profile of Boswellia serrata. Asian J Pharm Clin Res. https://doi.org/10.22159/ajpcr.2019.v12i5.31260
Taur DJ, Patil RY (2011) Some medicinal plants with antiasthmatic potential: a current status. Asian Pac J Trop Biomed 1(5):413–418. https://doi.org/10.1016/S2221-1691(11)60091-9
Thaker K, Patoliya J, Rabadiya K, Reddy NRR, Joshi R (2023) Senna (Cassia angustifolia Vahl.): a comprehensive review of ethnopharmacology and phytochemistry. Pharmacol Res Nat Prod 1:100003. https://doi.org/10.1016/j.prenap.2023.100003
Thakur S, Chaudhary G (2021) Review based upon Ayurvedic and traditional uses of Cinnamomum tamala (Tejpatta). Int J Pharm Sci Rev Res. https://doi.org/10.47583/ijpsrr.2021.v68i02.011
Thakur S, Kumari I, Chaudhary S, Kaurav H, Chaudhary G (2021a) Coriander (Coriandrum sativum): a common Indian traditional spice and Ayurvedic remedy. Int J Res Ayurveda Pharm 12:74–81. https://doi.org/10.7897/2277-4343.120250
Thakur S, Walia B, Chaudhary G (2021b) Dalchini (Cinnamomum zeylanicum): a versatile spice with significant therapeutic potential: Cinnamomum zeylanicum. Int J Pharm Drug Anal. https://doi.org/10.47957/ijpda.v9i2.467
Tiwari BR, Naseeruddin Inamdar M, Orfali R, Alshehri A, Alghamdi A, Almadani ME, Alshehri S, Imam Rabbani S, Mohammed Basheeruddin Asdaq S (2023) Comparative evaluation of the potential anti-spasmodic activity of Piper longum, Piper nigrum, Terminalia bellerica, Terminalia chebula, and Zingiber officinale in experimental animals. Saudi Pharm J 31(9):101705. https://doi.org/10.1016/j.jsps.2023.101705
Tripathi P (2006) Medicinal properties of onion and garlic. National Research Centre for Onion and Garlic, Rajgurunagar. https://doi.org/10.13140/RG.2.1.1081.0485
Udayakumar R, Kasthurirengan S, Vasudevan A, Mariashibu TS, Rayan JJS, Choi CW, Ganapathi A, Kim SC (2010) Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats. Plant Foods Hum Nutr (dordrecht, Netherlands) 65(2):91–98. https://doi.org/10.1007/s11130-009-0146-8
Verma SK, Pandey M, Khare R, Singh D (2024) A review on non-small cell lung cancer. Vacunas. https://doi.org/10.1016/j.vacun.2023.12.003
Wani MC, Horwitz SB (2014) Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anticancer Drugs 25(5):482–487. https://doi.org/10.1097/CAD.0000000000000063
Wichers HJ, Visser JF, Huizing HJ, Pras N (1993) Occurrence of L-DOPA and dopamine in plants and cell cultures ofMucuna pruriens and effects of 2,4-d and NaCl on these compounds. Plant Cell Tissue Organ Cult 33(3):259–264. https://doi.org/10.1007/BF02319010
Wu L, Chen W, Wang Z (2021) Traditional Indian medicine in China: the status quo of recognition, development and research. J Ethnopharmacol 279:114317. https://doi.org/10.1016/j.jep.2021.114317
Xiong L, Chen C-F, Min T-L, Hu H-F (2019) Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No. 968 and their antitumor activities in vitro. Chin J Nat Med 17(2):155–160. https://doi.org/10.1016/S1875-5364(19)30018-4
Yadav A, Garg S, Gupta R, Gangwar N, Sonwalkar P, Nayak V, Handa AK, Alam B, Arunachalam A (2023) Importance and uses of Ankol (Alangium salvifolium). 4:44–46
Acknowledgements
The authors thank Shri Ramswaroop Memorial University, Barabanki (UP), India, for continuous support and assistance during research work and scientific writing. The authors also thank the in-house seed grant project [File No. FY-2023-24/SMG/001, 24th Jan. 2024] and [File No. FY-2023-24/SMG/002, 24th Jan. 2024] funded by Shri Ramswaroop Memorial University, Lucknow-Deva Road, Barabanki-225003, U.P., India.
Funding
No funding was obtained for this study.
Author information
Authors and Affiliations
Contributions
SKV and DS conceived the idea and wrote the manuscript, drew figures and tables, and MP and AS read, edited, revise and proofread the manuscript. All authors have read and approved the manuscript.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Verma, S.K., Pandey, M., Sharma, A. et al. Exploring Ayurveda: principles and their application in modern medicine. Bull Natl Res Cent 48, 77 (2024). https://doi.org/10.1186/s42269-024-01231-0
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s42269-024-01231-0