Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Schwartzman ML et al (2014) CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype. Hypertension 64(6):1352–1361
Article
CAS
Google Scholar
Ashcroft FM, Rorsman P (2013) K (ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol 9:660–669
Article
CAS
Google Scholar
Campbell WB, Fleming I (2010) Epoxyeicosatrienoic acids and endothelium-dependent responses. Pflugers Archiv 459(6):881–895
Article
CAS
Google Scholar
Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C et al (2013) Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins Other Lipid Mediat 104–105:42–48
Article
Google Scholar
Chen, L.B Jiang, X.B Yang, L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 2004; 10(20):3016–3020
Article
CAS
Google Scholar
Dominici M, le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315–317
Article
CAS
Google Scholar
Falck JR, Manna S, Moltz J, Chacos N, Capdevila J (1983) Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochem Biophys Res Commun 114:743–749
Article
CAS
Google Scholar
Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D et al (1990) Expression of the CD34 gene in vascular endothelial cells. Blood 75:2417–2426
CAS
PubMed
Google Scholar
Friedenstein AJ, Gorskaja JF, Kulagina NN (1976) Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4:267–274
CAS
PubMed
Google Scholar
Gabr MM, Zakaria MM, Refaie AF, Ismail AM, Ashamallah SA, Khater SM, El-Halawani SM, Ghoneim MA et al (2013) Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant 22(1):133–145
Article
Google Scholar
Gabr MM, Zakaria MM, Refaie AF, Khater SM, Ashamallah SA, Ismail AM, el-Halawani SM, Ghoneim MA (2015) Differentiation of human bone marrow-derived mesenchymal stem cells into insulin-producing cells: evidence for further maturation in vivo. Biomed Res Int 2015:e575837
Article
Google Scholar
Gang YU, Xiying WU, Dietrich MA, Polk PL, Scott K, Ptitsyn AA, Gimble JM (2010) Yield and characterization of subcutaneous human adipose-derived stem cells by flow cytometric and adipogenic mRNA analyses. Cytotherapy 12:538–546
Article
Google Scholar
Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Caskey CF et al (2017) Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Diabetologia 60:1066–1107
Article
CAS
Google Scholar
Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MC, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P (2004) Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53(10):2603–2609
Article
CAS
Google Scholar
Hass R, Kasper C, Bohm S, Jacobs R (2011) Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 9:12
Article
CAS
Google Scholar
Jafarian A, Taghikani M, Abroun S, Allahverdi A, Lamei M, Lakpour N, Soleimani M (2015) The generation of insulin-producing cells from human mesenchymal stem cells by MiR-375 and anti-MiR-9. PLoS One 10(6):e0128650
Article
Google Scholar
Kang Y, Zhang Y, Liang T, Leung YM, Ng B, Xie H, Gaisano HY (2011) ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell KATP channels. J Biol Chem 286(7):5876–5883
Article
CAS
Google Scholar
Karara A, Dishman E, Falck JR, Capdevila JH (1991) Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J Biol Chem 266:7561–7569
CAS
PubMed
Google Scholar
Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S (2007) Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 25:2837–2844S
Article
CAS
Google Scholar
Kim DH, Vanella L, Inoue K, Burgess A, Gotlinger K, Manthati VL, Koduru SR et al (2010) Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell–derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARg. Stem Cells Dev 19:12
Google Scholar
Kim HS, Hwang YC, Koo SH, Park KS, Lee MS, Kim KW, Lee MK (2013) PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells. PLoS One 8(1):e50128
Article
ADS
CAS
Google Scholar
Klett EL, Chen S, Edin ML, Li LO, Ilkayeva O, Zeldin DC, Newgard CB, Coleman RA (2013a) Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. J Biol Chem 288:21618–21629
Article
CAS
Google Scholar
Klett EL, Chen S, Edin ML et al (2013b) Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. J Biol Chem 288(30):21618–21629
Article
CAS
Google Scholar
Lin G, Xin Z, Zhang H, Banie L, Wang G, Qiu X et al (2012) Identification of active and quiescent adipose vascular stromal cells. Cytotherapy 14:240–246
Article
CAS
Google Scholar
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔC
T method. Methods 25(4):402–408
Article
CAS
Google Scholar
Lu T, Hoshi T, Weintraub NL, Spector AA, Lee HC (2001) Activation of ATP-sensitive K+ channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J Physiol 537(3):811–827
Article
CAS
Google Scholar
Luo P, Chang HH, Zhou Y, Zhang S, Hwang SH, Morisseau C, Wang MH (2010) Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. J Pharmacol Exp Ther 334(2):430–438
Article
CAS
Google Scholar
Luo P, Wang MH (2011) Eicosanoids, β-cell function, and diabetes. Prostaglandins Other Lipid Mediat 95:1–4
Article
CAS
Google Scholar
Maleki M, Ghanbarv F, Behvarz MR, Ejtemaei M, Ghadirkhomi E (2014) Comparison of mesenchymal stem cell markers in multiple human adult stem cells. Int J Stem Cells 7:118–126
Article
CAS
Google Scholar
Mc Kiernan E, Barron NW, O’Sullivan F, Barham P, Clynes M, O’Driscoll L (2007) Detecting de novo insulin synthesis in embryonic stem cell-derived populations. Exp Cell Res 313(7):1405–1414
Article
CAS
Google Scholar
Moriscot C, De Fraipont F, Richard M, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou P (2005) Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 23(4):594–603
Article
CAS
Google Scholar
Mouiseddine M, Mathieu N, Stefani J, Demarquay C, Bertho JM (2008) Characterization and histological localization of multipotent mesenchymal stromal cells in the human postnatal thymus. Stem Cells Dev 17:1165–1174
Article
CAS
Google Scholar
Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK (1999) Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285:1276–1279
Article
CAS
Google Scholar
Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299(5605):363
PubMed
Google Scholar
Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, SEINO S (2004) Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem 279:7956–7961
Article
CAS
Google Scholar
Simmons PJ, Torok-Storb B (1991) Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 78:55–62
CAS
PubMed
Google Scholar
Sodhi K, Inoue K, Gotlinger KH, Canestraro M, Vanella L, Kim DH, Manthati VL et al (2009) Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-nullmice. J Pharmacol Exp Ther 331:906–916
Article
CAS
Google Scholar
Stolzing A, Bauer E, Scutt AM (2012) Suspension cultures of bone marrow derived mesenchymal stem cells: effects of donor age and glucose level. Stem Cells Dev 21(14):2718–2723
Article
CAS
Google Scholar
Suga H, Shigeura T, Matsumoto D, Inoue K, Kato H, Aoi N et al (2007) Rapid expansion of human adipose-derived stromal cells preserving multipotency. Cytotherapy 9:738–745
Article
CAS
Google Scholar
Sun Y, Chen L, Hou XG, Hou WK, Dong JJ, Sun L et al (2007) Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin Med J 120(9):771–776
CAS
PubMed
Google Scholar
Vanella L, Kim DH, Asprinio D, Peterson SJ, Barbagallo I, Vanella A, Abraham NG (2010) HO-1 expression increases mesenchymal stem cell-derived osteoblast but decreases adipocyte lineage. Bone 46(1):236
Article
CAS
Google Scholar
Vanella L, Kim DH, Sodhi K, Barbagallo I, Burgess AP, Falck JR, Abraham NG (2011) Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. Prostaglandins Other Lipid Mediat 96:54–62
Article
CAS
Google Scholar
Volarevic V, Al-Qahtani A, Arsenijevic N, Pajovic S, Lukic ML (2010) Interleukin-1receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity 43:255–263
Article
CAS
Google Scholar
Wang Y, Wei X, Xiao X, Hui R, Card JW, Carey MA, Wang DW, Zeldin DC (2005) Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways. J Pharmacol Exp Ther 314:522–532
Article
CAS
Google Scholar
Watt SM, Karhi K, Gatter K, Furley AJ, Katz FE, Healy LE et al (1987) Distribution and epitope analysis of the cell membrane glycoprotein (HPCA-1) associated with human hemopoietic progenitor cells. Leukemia 1:417–426
CAS
PubMed
Google Scholar
Wray J, Bailey DB (2007) Epoxygenases and peroxisome proliferator-activated receptors in mammalian vascular biology. Exp Physiol 93(1):148–154
Article
Google Scholar
Xie H, Wang Y, Zhang H, Qi H, Zhou H, Li FR (2013) Role of injured pancreatic extract promotes bone marrow-derived mesenchymal stem cells efficiently differentiate into insulin-producing cells. PLoS One 8(9):e76056
Article
ADS
CAS
Google Scholar
Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL (2009) Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon micro-environmental manipulation in vitro. Differentiation 77:483–491
Article
CAS
Google Scholar
Xin Y, Jiang X, Wang Y, Su X, Sun M, Zhang L et al (2016) Insulin-producing cells differentiated from human bone marrow mesenchymal stem cells in vitro amel iorate streptozotocin-induced diabetic hyperglycemia. PLoS ONE 11(1):e0145838
Article
Google Scholar
Xu M, Ju W, Hao H, Wang G, Li P (2013) Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance. Drug Metab Rev 45(3):311–352
Article
CAS
Google Scholar
Zanini C, Bruno S, Mandili G, Baci D, Cerutti F, Cenacchi G, Izzi L, Camussi G, Forni M (2011) Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype. PLoS One 6(12):e28175
Article
ADS
CAS
Google Scholar
Zeldin DC, Foley J, Boyle JE, Moomaw CR, Tomer KB, Parker C, Steenbergen C, Wu S (1997) Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas. Endocrinology 138:1338–1346
Article
CAS
Google Scholar