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Bulletin of the National Research Centre

Table 2 Relative expression of PDX-1, insulin, CYP2J2 genes, and 14, 15-DHET conc. level before and after differentiation of HBM-MSCs to IPCs

From: The expression of cytochrome P4502J2 gene and 14, 15 epoxyeicosatrienoic acid level influence the amount of insulin secreted from human mesenchymal stem cell-derived insulin-producing cells

 

Undifferentiated HBM-MSCs

Differentiated IPCs

P value

PDX-1

1.0 ± 0.03

5.5 ± 0.9

0.046*

Insulin

1.0 ± 0.02

3.0 ± 0.2

0.04*

CYP2J2

1.0 ± 0.37

0.84 ± 0.01

0.31

14-15DHET (pg/mL)

4.85 ± 0.6

3.36 ± 0.4

0.005*

  1. *Statistically significant difference (P value < 0.05)
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