Fabrication, design, and in vivo investigation of mesoporous silica-based docetaxel trihydrate nanoparticles for colonic drug delivery

Bulletin of the National Research Centre

Table 4 Summary of ANOVA for response surface quadratic models

Source	Sum of square	Degree of freedom	Mean square	F-value	P-value prob > F
Entrapment efficiency (%)
Model	1048.28	2	524.14	46.15	0.0002
A	970.45	1	970.45	85.45	< 0.0001
B	77.83	1	77.83	6.85	0.0397
AB	165.38	1	165.38	0.5546	0.0510
A²	1.28	6	11.36	0.0043	0.0951
B²	0.5408	1	0.5408	0.0018	0.0968
Drug release at 6 h (%)
Model	479.78	2	239.89	60.24	0.0001
A	451.83	1	451.83	113.47	< 0.0001
B	27.95	1	27.95	7.02	0.0381
AB	1021.44	1	70.81	0.5408	0.0515
A²	2.52	1	2.52	0.0193	0.0898
B²	0.9339	1	0.9339	0.0071	0.9380
Drug release at 10 h (%)
Model	1097.12	2	548.56	52.08	0.0002
A	993.20	1	993.20	94.29	< 0.0001
B	103.92	1	103.92	9.87	0.0200
AB	122.77	1	122.77	0.3766	0.05828
A²	0.2813	1	0.2813	0.0009	0.9784
B²	0.0968	1	0.0968	0.0003	0.9873