Fabrication, design, and in vivo investigation of mesoporous silica-based docetaxel trihydrate nanoparticles for colonic drug delivery

Bulletin of the National Research Centre

Table 3 Different release kinetic of mesoporous silica nanoparticles

Formulation	Zero order		First order		Higuchi mechanism		Korsmeyer–Peppas
Formulation	R²	n	R²	n	R²	n	R²	n
F1	0.949	7.586	0.909	− 0.063	0.884	31.28	0.941	1.135
F2	0.944	7.914	0.913	− 0.062	0.890	32.85	0.957	1.324
F3	0.940	6.540	0.921	− 0.042	0.867	26.71	0.938	1.494
F4	0.898	6.041	0.880	− 0.038	0.834	24.88	0.921	1.401
F5	0.908	4.423	0.854	− 0.026	0.839	18.17	0.974	1.380
F6	0.940	7.259	0.911	− 0.051	0.884	30.09	0.971	1.522
F7	0.936	7.813	0.908	− 0.059	0.876	32.31	0.952	1.394
F8	0.881	4.986	0.856	− 0.027	0.806	20.38	0.998	1.836
F9	0.909	5.267	0.896	− 0.030	0.830	21.51	0.918	1.467