Table 1 32 factorial design with the experimental response values for the various formulation of pH-dependent mesoporous silica-loaded docetaxel trihydrate nanoparticles
Formulation code | Factors (levels) | Responses | |||
|---|---|---|---|---|---|
Ratio of eudragit S100 and L100 (mg) (A) | Phosphatidylcholine (mg) (B) | Entrapment efficiency (%) | Drug release at 6Â h (%) | Drug release at 10Â h (%) | |
F1 | 200 (+ 1) | 60 (0) | 78.38 | 34.31 | 73.39 |
F2 | 200 (+ 1) | 40 (− 1) | 76.6 | 32.09 | 71.45 |
F3 | 100 (0) | 60 (0) | 64.77 | 24.24 | 57.16 |
F4 | 100 (0) | 80 (+ 1) | 59.6 | 20.03 | 53.38 |
F5 | 40 (− 1) | 40 (− 1) | 55.22 | 18.26 | 49.28 |
F6 | 100 (0) | 40 (− 1) | 69.66 | 26.89 | 64.74 |
F7 | 200 (+ 1) | 80 (+ 1) | 75.44 | 31.87 | 68.48 |
F8 | 40 (− 1) | 80 (+ 1) | 44.83 | 12.39 | 38.74 |
F9 | 40 (− 1) | 60 (0) | 52.88 | 15.16 | 47.03 |