Understanding the health risks and emerging concerns associated with the use of long-term proton pump inhibitors

Bulletin of the National Research Centre

Table 2 Bacteria families present in the gastroinestinal tract that are altered in at least two studies

Bacteria family	Bacterial population in response to PPIs
Enterococcaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Freedberg et al. 2015); (12 healthy volunteers)
Lactobacillaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects)
Micrococcaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects) (Freedberg et al. 2015) (12 healthy volunteers)
Pasteurellaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects)
Ruminococcaceae	Decreased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects)
Staphylococcaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects) (Freedberg et al. 2015) (12 healthy volunteers)
Streptococcaceae	Increased (Imhann et al. 2016); (cross sectional study 1815 subjects) (Jackson et al. 2016); (cross sectional study 1827 subjects) (Freedberg et al. 2015) (12 healthy volunteers)