Table 2 Genes and susceptibility genes involved in Parkinson’s disease (PD) (Chia et al. 2020)
Sr.no | Gene symbol | Locus name | Type of mutation | Protein product | Mode of inheritance |
|---|---|---|---|---|---|
1 | PINK1 | PARK6 | Missense, frameshift, splice site, point, truncating | PTEN-induced putative kinase 1 | AR |
2 | SNCA | PARK1 | Missense, point | Alpha-synuclein | AD |
3 | PRKN | PARK2 | Missense, frameshift, splice site, point, nonsense | Parkin | AR |
4 | ATP13A2 | PARK9 | Frameshift | ATPase 13A2 | AR |
5 | DJ-1 | PARK7 | Point, missense, frameshift, exon deletion, and slice site frameshift | Protein DJ-1 | AR |
6 | LRRK2 | PARK8 | Missense | Leucin-rich protein kinase 2 | AD |