Table 1 Drug-induced neurotoxicity in Parkinson’s disease (PD) (SNC: substantia nigra compacta; MFB: medial forebrain bundle; IC: intracerebral injection; IP: intraperitoneal injection; SC: subcutaneous injection) (Vaccari et al. 2019)
Sr. no | Neurotoxin | Dose | Animal species | Route of administration |
|---|---|---|---|---|
1 | 6-OHDA | 0.032 mg/kg 0.05 mg/kg 0.02–0.16 mg/kg 0.05–0.32 mg/kg | Rat or mice Rat Mice Rat or mice | I.C. into SNC I.C. into MFB I.C. into MFB I.C. into striatum |
2 | MPTP | 33 nmol/24 h 15–20 mg/kg 46 mg/kg 23 mg/kg | Rat Mice Mice Mice | I.C. into SNC/striatum I.P I.P. infusion S.C |
3 | Paraquat | 10 mg/kg 10–15 mg/kg | Mice Rat or mice | Oral I.P |
4 | Rotenone | 2–3 mg/kg 5.0 µg 2.75–3.0 mg/kg 50 mg/kg | Rat Rat Rat Mice | S.C. infusion I.C I.P oral |