Origanum majorana L. extract alleviates dexamethasone-induced hepatotoxicity, oxidative stress and pathological alterations in vivo

Bulletin of the National Research Centre

Table 1 O. majorana aqueous extract preventative role of on serum activities of ALT, AST, ALP and LDH against DXM treatment

Parameters Treatments	Serum ALT IU/L	% change	Serum AST IU/L	% change	Serum ALP IU/L	% change	Serum LDH IU/L	% change
G1 Control	55.9 ± 1.8	–	173.7 ± 2.18	–	183.0 ± 3.6	–	2481.0 ± 16.4	–
G2 DXM	77.9 ± 4.0***	39.4	264.0 ± 5.5 ***	51.99	303.2 ± 3.5 ***	65.57	2563 ± 21.7 ***	3.3
G3 DXM + O. majorana	54.2 ± 2.2 ***	− 30.4	234.0 ± 3.2***	− 11.36	180.0 ± 2.3 ***	− 40.59	2278 ± 9.3 ***	− 11.1
F-Probability	P < 0.0001	–	P < 0.0001	–	P < 0.0001	–	P < 0.0001	–

Data are mean ± SE, (n = 6), G1 compared to G2 and G3 compared to G2
DXM Dexamethasone
*, ** and ***Indicate significant change from control, DXM, and DXM + O. majorana, respectively, at P < 0.0001