Bulletin of the National Research Centre

Table 4 ADMET profiles of B-1, B-2 and R

From: Design, pharmacokinetic profiling, and assessment of kinetic and thermodynamic stability of novel anti-Salmonella typhi imidazole analogues

Ligand	CYP45 inhibitor	ESOL (mg/ml)	GIA	P-gp⁺	BBB	MUT	TUM	IR	RE
B-1	Yes	0.006	High	No	No	Yes	None	None	Yes
B-2	Yes	0.009	High	No	No	Yes	None	None	Yes
R	No	15.7	High	Yes	No	None	None	None	None

ESOL estimated solubility, GIA gastrointestinal absorption, BBB blood brain barrier penetration, P-gp⁺ P-glycoprotein substrate, MU mutagenicity, TUM tumorigenic, IR irritating effect, RE reproductive effect

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