rs2470893 SNP genotype | Number of coffee cups/day mean (SD) | Number of tea cups/day mean (SD) | rs762551 SNP genotype | Number of coffee cups/day mean (SD) |
---|---|---|---|---|
Nonsmokers | ||||
GG (N = 197) | 0.73 (0.73) | 0.44 (0.81) | AA + AC (N = 243) | 0.95(0.84) |
*GA + AA (N = 63) | 1.22 (0.92) | 0.11 (0.19) | *CC (N = 17) | 0.99(0.83) |
p | 0.000 | 0.002 | p | 0.83 |
OR (95% CI) | 1.64 (1.30–2.06) | 0.72 (0.58–0.89) | OR (95% CI) | – |
η2p | 0.068 | 0.036 | η2p | – |
pa | 0.000 | 0.000 | pa | – |
OR (95% CI) | 1.64 (1.25–2.14) | 0.62 (0.50–0.78) | OR (95% CI) | – |
η2p | 0.055 | 0.070 | η2p | – |
Smokers | ||||
GG (N = 218) | 2.00 (1.21) | 0.24 (0.38) | AA + AC (N = 233) | 2.02 (1.20) |
*GA + AA (N = 42) | 2.50 (0.96) | 0.14 (0.33) | *CC (N = 27) | 2.75 (1.28) |
p | 0.017 | 0.12 | p | 0.011 |
OR (95% CI) | 1.63 (1.09–2.44) | – | OR (95% CI) | 2.07 (1.18–3.62) |
η2p | 0.022 | – | η2p | 0.028 |
pa | 0.098 | – | pa | 0.000 |
OR (95% CI) | – | – | OR (95% CI) | 2.50 (1.50–4.16) |
η2p | – | – | η2p | 0.055 |
Age ≤ 35 | ||||
GG (N = 225) | 1.38 (1.24) | 0.19 (0.41) | AA + AC (N = 250) | 1.41 (1.18) |
*GA + AA (N = 50) | 1.90 (0.88) | 0.12 (0.31) | *CC (N = 20) | 2.5 (0.42) |
p | 0.009 | 0.32 | p | 0.001 |
OR (95% CI) | 1.67 (1.14–2.46) | – | OR (95% CI) | 2.95 (1.60–5.42) |
η2p | 0.027 | – | η2p | 0.051 |
pa | 0.003 | – | pa | 0.15 |
OR (95% CI) | 1.63 (1.18–2.25) | – | OR (95% CI) | – |
η2p | 0.035 | – | η2p | – |
Age > 35 | ||||
GG (N = 190) | 1.49 (1.17) | 0.47 (0.73) | AA + AC (N = 226) | 1.48 (1.04) |
*GA + AA (N = 55) | 1.34 (0.82) | 0.24 (0.32) | *CC (N = 24) | 1.83 (1.99) |
p | 0.38 | 0.033 | p | 0.25 |
OR (95% CI) | – | 0.79 (0.64–0.98) | OR (95% CI) | – |
η2p | – | 0.020 | η2p | – |
pa | – | 0.000 | pa | – |
OR (95% CI) | – | 0.64 (0.52–0.79) | OR (95% CI) | – |
η2p | – | 0.071 | η2p | – |
Gender (F) | ||||
GG (N = 90) | 0.92 (1.36) | 0.53 (1.02) | AA + AC (N = 106) | 1.28 (1.56) |
*GA + AA (N = 25) | 2.02 (1.67) | 0.11 (0.16) | *CC (N = 9) | 0.00 (0.00) |
p | 0.001 | 0.045 | p | 0.069 |
OR (95% CI) | 3.01 (1.58–5.73) | 0.65 (0.43–0.99) | OR (95% CI) | – |
η2p | 0.093 | 0.035 | η2p | – |
pa | 0.000 | 0.000 | pa | – |
OR (95% CI) | 3.38 (1.92–5.94) | 0.34 (0.20–0.59) | OR (95% CI) | – |
η2p | 0.168 | 0.141 | η2p | – |
Gender (M) | ||||
GG (N = 325) | 1.54 (1.10) | 0.29 (0.46) | AA + AC (N = 370) | 1.48 (1.02) |
*GA + AA (N = 80) | 1.59 (0.95) | 0.18 (0.34) | *CC (N = 35) | 2.60 (1.18) |
p | 0.67 | 0.05 | p | 0.000 |
OR (95% CI) | – | 0.89 (0.80–0.99) | OR (95% CI) | 3.05 (2.00–4.65) |
η2p | – | 0.010 | η2p | 0.068 |
pa | – | 0.002 | pa | 0.000 |
OR (95% CI) | – | 0.84 (0.75–0.93) | OR (95% CI) | 2.07 (1.37–3.12) |
η2p | – | 0.025 | η2p | 0.034 |