From: Chronicle updates in cyclodextrin-based carriers for drug delivery
Bioavailability (plasma concentration) in rats | Indomethacin–CD complex: higher than free indomethacin throughout study time range |
Pregnancy protection study in rabbit | Control: 16% alive foeti Free indomethacin: 58.8% Indomethacin–CD complex: 66.7% (insignificantly higher than free indomethacin) |
Anti-inflammatory activity in rats | Indomethacin–CD complex: insignificant at lower dose while significant at higher dose with respect to equivalent free indomethacin |
Duration of anti-inflammatory activity in rats | Indomethacin: showed un-observable activity if given after 48 h of carrageenan induction of inflammation Indomethacin–CD complex: retained activity even if given after 6 h |
Speed of anti-inflammatory activity | Indomethacin–CD complex: higher speed of inflammation |
Ulcerative toxicity in rats | Indomethacin–CD 1:1 complex caused more ulcerative toxicity than free drug |