Computational evaluation of bioactive compounds from Vitis vinifera as a novel β-catenin inhibitor for cancer treatment

Bulletin of the National Research Centre

Table 2 SwissADME pharmacokinetic profile of the lead and standard compounds

Compound	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
Cis-astringin	Low	No	No	No	No	No	No	No
Rutin	Low	No	Yes	No	No	No	No	No
Caftaric acid	Low	No	No	No	No	No	No	No
Trans-caftaric acid	Low	No	No	No	No	No	No	No
Procyanidin B3	Low	No	No	No	No	No	No	Yes
Cis-miyabenol C	Low	No	No	No	No	No	No	No
Ampelopsin H	Low	No	Yes	No	No	No	No	No
Leucovorin calcium	Low	No	Yes	No	No	No	No	No
Xeloda	High	No	Yes	No	No	No	No	No