Computational modeling, ligand-based drug design, drug-likeness and ADMET properties studies of series of chromen-2-ones analogues as anti-cancer agents

Bulletin of the National Research Centre

Table 2 Minimum recommended values for acceptable QSAR model

Symbol	Name	Threshold limit	Model 1	Model 2	Model 3	Model 4
LOF	Friedman’s lack of fit	Low value	0.016488	0.01648900	0.01683500	0.01705300
R²	Co-efficient of determination of the training set	≥ 0.6	0.94794	0.94793800	0.94684500	0.94615500
R_adj²	Adjusted R-squared	≥ 0.6	0.935	0.93544300	0.93408800	0.93323200
Q²	Cross-validation coefficient	≥ 0.5	0.912	0.91105100	0.90975700	0.90712400
R²-Q²	Difference between R² and Q²	< 0.3	0.012494	0.036887	0.037088	0.039031