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Bulletin of the National Research Centre

Table 8 Drug-likeness properties of the designed analogues

From: Salicylic acid derivatives as potential α-glucosidase inhibitors: drug design, molecular docking and pharmacokinetic studies

 

Molecular weight

H-bond acceptor

H-bond donor

MLog P

Lipinski’s violations

Bioavailability score

Synthetic accessibility

A1

466.33

5

2

3.66

0

0.55

3.33

A2

500.78

5

2

4.13

1

0.55

3.38

A3

555.24

5

2

3.87

1

0.55

3.35

A4

634.13

5

2

4.45

1

0.17

3.43

A5

555.24

5

2

3.87

1

0.55

3.37

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