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Table 3 Impact of high dietary fructose on blood glucose, insulin concentration and HOMA-IR of adolescent (post-natal day 63) male and female rats administered curcumin during suckling

From: Neonatal orally administered curcumin: impact on the metabolic response and renal histology of Sprague-Dawley rats fed a high-fructose diet until adolescence

Treatment groups

Blood glucose (mg dl−1)

Insulin (ng ml−1)

HOMA-IR

Male rats

DMSO + TW

74.00 ± 3.40a

4.80 ± 1.20b

0.91 ± 0.25c

DMSO + FW

81.00 ± 4.00a

4.30 ± 1.10b

0.81 ± 0.20c

CC + TW

71.00 ± 0.85a

5.70 ± 1.10b

0.99 ± 0.20c

CC + FW

73.00 ± 2.20a

4.70 ± 1.20b

0.85 ± 0.21c

FW + TW

81.00 ± 4.50a

3.50 ± 0.83b

0.68 ± 0.16c

FW + FW

73.00 ± 2.00a

6.40 ± 1.00b

1.20 ± 0.18c

CCFW + TW

79.00 ± 5.50a

5.20 ± 0.94b

0.99 ± 0.16c

CCFW + FW

80.00 ± 4.10a

4.30 ± 0.99b

0.81 ± 0.15c

p values

0.243

0.629

0.745

Female rats

DMSO + TW

78.00 ± 3.50a

4.40 ± 0.10b

0.88 ± 0.24c

DMSO + FW

78.00 ± 2.90a

5.60 ± 0.95b

1.10 ± 0.20c

CC + TW

77.00 ± 1.80a

5.60 ± 0.11b

0.94 ± 0.23c

CC + FW

71.00 ± 2.90a

4.60 ± 0.93b

0.83 ± 0.17c

FW + TW

73.00 ± 5.20a

3.40 ± 0.56b

0.62 ± 0.12c

FW + FW

72.00 ± 1.80a

4.40 ± 0.11b

0.81 ± 0.23c

CCFW + TW

76.00 ± 2.20a

5.40 ± 0.10b

0.88 ± 0.22c

CCFW + FW

72.00 ± 2.30a

6.30 ± 0.86b

1.10 ± 0.16c

p values

0.408

0.529

0.648

  1. a, b, cMeans across columns (in males and females) with similar superscripts are similar (p > 0.05) using one-way ANOVA across all eight groups. Using ANOVA between all eight groups for fasting blood glucose, plasma insulin concentration and HOMA-IR of the male and female rats. FBG, fasting blood glucose; HOMA-IR, homeostatic model of insulin resistance. DMSO + TW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and plain tap water post-weaning, DMSO + FW = 10 ml kg−1 of a 0.5% dimethyl sulphoxide solution as neonates and fructose (20%, w/v) as drinking fluid post-weaning, CC + TW = curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and plain tap water post-weaning, CC + FW =  curcumin (500 mg kg−1 in 0.5% DMSO) as neonates and fructose (20%, w/v) as drinking fluid post-weaning, FW + TW = fructose (20%, w/v) as neonates and plain tap water post-weaning, FW + FW = fructose (20%, w/v) as neonates and fructose (20%, w/v) as drinking fluid post-weaning, CCFW + TW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and plain tap water post-weaning, CCFW + FW = curcumin (500 mg kg−1) and fructose (20%, w/v) in 0.5% DMSO as neonates and fructose (20%, w/v) post-weaning. Data expressed as mean ± SEM, n = 7–9 per group