From: Formulation and optimization of polymeric agglomerates of Bosentan monohydrate by crystallo-co-agglomeration technique
Properties
Pure drug
Spherical agglomerates
Angle of repose
47.33 ± 1.154
30.33 ± 0.35
Carr’s index
36.44 ± 0.509%
13.46 ± 0.058%
Hausner’s ratio
1.55 ± 0.02
1.08 ± 0.063
% Yield
93 ± 0.054%
Drug content
92.65 ± 0.215%