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Bulletin of the National Research Centre

Table 8 Optimized batch with desirability function

From: Formulation and optimization of polymeric agglomerates of Bosentan monohydrate by crystallo-co-agglomeration technique

Batch

Talc (mg)

PEG6000 (mg)

Speed (RPM)

Particle size (µm) (Y1)

Angle of repose (Y2)

Drug content % (Y3)

Predicted

Actual

Predicted

Actual

Predicted

Actual

BOS 16

2.28

10

600

12.16

11.56 ± 0.89

30.48

30.33 ± 0.35

88.01

92.65 ± 0.215

  1. Mean ± SD = 3, n = 3
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