Table 10 Physicochemical evaluation during stability study
Condition | Hardness (kg/cm2) | Thickness (mm) | Diameter (mm) | Friability (%) | Weight variation (mg) | Drug content (%) | DT (sec.) | % Drug release |
|---|---|---|---|---|---|---|---|---|
Initial | 5.44 ± 0.136 | 3.15 ± 0.125 | 4.0 ± 0.02 | 0.68 ± 0.32 | 250.25 ± 0.42 | 92.71 ± 0.284 | 41.33 ± 1.312 | 94.65 ± 0.524 |
After 1 month | ||||||||
40 ± 2 °C/75 ± 5% RH | 5.41 ± 0.254 | 3.14 ± 0.174 | 4.0 ± 0.01 | 0.66 ± 0.36 | 250.11 ± 0.43 | 92.37 ± 0.455 | 39.09 ± 1.34 | 92.47 ± 0.464 |
After 3 months | ||||||||
40 ± 2 °C/75 ± 5% RH | 5.39 ± 0.254 | 3.14 ± 0.223 | 4.0 ± 0.01 | 0.65 ± 0.54 | 250.10 ± 0.49 | 91.80 ± 0.5342 | 38.34 ± 1.446 | 91.40 ± 0.415 |