Antiplasmodial and in vitro antioxidant potentials of crude aqueous and methanol extracts of Chasmanthera dependens (Hochst)

Bulletin of the National Research Centre

Table 6 Threshold inhibitory concentration (IC₅₀) of crude aqueous and methanol extracts of C. dependens and ascorbic acid standard on hydrogen peroxide radicals

Extracts	Threshold inhibitory concentration (*IC₅₀)	Mathematical model	Equation	R²
CDRM	0.90 ± 0.09	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.931
CDLM	1.17 ± 0.17	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.920
CDSM	1.16 ± 0.15	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.915
CDRA	0.71 ± 0.07	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.915
CDLA	0.93 ± 0.11	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.911
CDSA	0.59 ± 0.11	Sigmoid (a, b, c)	\(y=\frac{a}{1 +\mathrm{exp}\left(-\left(\frac{x-{x}_{0}}{b}\right)\right)}\)	0.810
AA	0.38 ± 0.01	Logistic dose response (a, b, c)	\(y=\frac{a}{1 +{\left(\frac{x}{b}\right)}^{c}}\)	0.999

CDRM, C. dependens root methanol; CDLM, C. dependens leaves methanol; CDSM, C. dependens stem methanol; CDRA, C. dependens root aqueous; CDLA, C. dependens leaves aqueous; CDSA, C. dependens stem aqueous; AA, ascorbic acid
*IC₅₀ is the concentration of extract or standard that scavenged 50% of the generated free radicals