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Table 3 Comparison of estimated death tolls of pandemics (the numbers may vary from site to site).

From: Cross-species virus transmission and its pandemic potential

Pandemic

Year

Death count

Notes

Antonine Plague

165 AD

5 million

The cause is yet unknown although it is thought to have been measles or smallpox

The Black death

1346–1353

75–200 million

Lead to mass deaths and devastation across three continents. Causative agent: Yersinapestis

Third Cholera pandemic

1852–1860

1 million

Considered to be the most deadliest of all the cholera pandemics; Originated in India

“Russian flu”

1889–1890

1 million

Causative agent: Influenza A virus subtype H3N8

Sixth Cholera pandemic

1910–1911

800,000 + 

“Spanish flu”

1918

20–50 million

Affected young and healthy individuals; infected over a third of the world’s population

“Asian flu”

1956–1958

2 million

SARS

2002–2003

774

MERS

2012

912

COVID-19

2019–2020

324,000 + 

As of 20th May 2020