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Bulletin of the National Research Centre

Table 2 Effect of each of l-dopa and rasagiline (R) alone or in combination with caffeine (CAF) or coffee (COF) on mean area percentage and mean optical density of GFAP+ve astrocytes in brain tissue sections in paraquat (PQ)-treated mice

From: Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

Groups

Mean area percentage

Mean optical density

Control

3.44 ± 0.48

69.94 ± 1.26

Paraquat

7.68 ± 1.52*

96.07 ± 0.26*

l-dopa

3.17 ± 0.23#

83.61 ± 0.81*#

l-dopa + CAF

3.39 ± 0.34#

71.13 ± 1.67#$

l-dopa + COF

3.25 ± 0.91#

76.98 ± 1.30*#$€

R

2.01 ± 0.59#

95.28 ± 0.51*

R + CAF

3.01 ± 0.31#

87.98 ± 0.58*#&

R + COF

2.35 ± 1.00#

92.01 ± 0.43*#&π

  1. Values are presented as mean ± S.E.M. *Significant from normal group P < 0.05. #Significant from paraquat group P < 0.05. $Significant from l-dopa group P < 0.05. €Significant from l-dopa + CAF group P < 0.05. &Significant from R group P < 0.05. πSignificant from R + CAF group P < 0.05
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