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Table 2 Effect of each of l-dopa and rasagiline (R) alone or in combination with caffeine (CAF) or coffee (COF) on mean area percentage and mean optical density of GFAP+ve astrocytes in brain tissue sections in paraquat (PQ)-treated mice

From: Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

Groups Mean area percentage Mean optical density
Control 3.44 ± 0.48 69.94 ± 1.26
Paraquat 7.68 ± 1.52* 96.07 ± 0.26*
l-dopa 3.17 ± 0.23# 83.61 ± 0.81*#
l-dopa + CAF 3.39 ± 0.34# 71.13 ± 1.67#$
l-dopa + COF 3.25 ± 0.91# 76.98 ± 1.30*#$€
R 2.01 ± 0.59# 95.28 ± 0.51*
R + CAF 3.01 ± 0.31# 87.98 ± 0.58*#&
R + COF 2.35 ± 1.00# 92.01 ± 0.43*#&π
  1. Values are presented as mean ± S.E.M. *Significant from normal group P < 0.05. #Significant from paraquat group P < 0.05. $Significant from l-dopa group P < 0.05. Significant from l-dopa + CAF group P < 0.05. &Significant from R group P < 0.05. πSignificant from R + CAF group P < 0.05