Table 1 Effect of each of l-dopa and rasagiline (R) alone or in combination with caffeine (CAF) or coffee (COF) on mean area percentage of neuronal cells and pigmented neurons as well as mean optical density of pigmented neurons in brain tissue sections in paraquat (PQ)-treated mice

0.51 ± 0.06

0.31 ± 0.04

99.41 ± 4.80

0.12 ± 0.02^*

0.05 ± 0.01^*

24.57 ± 1.21^*

0.26 ± 0.03^*

0.46 ± 0.07^*#

127.83 ± 0.91^*#

0.44 ± 0.10^#$

0.27 ± 0.04^#$

112.21 ± 5.29^*#$

0.21 ± 0.01^*€

0.24 ± 0.02^#$

116.87 ± 3.25^*#

0.09 ± 0.03^*

0.12 ± 0.02^*

166.05 ± 7.42^*#

0.13 ± 0.02^*

0.16 ± 0.02^*

135.83 ± 3.51^*#&

0.12 ± 0.02^*

0.13 ± 0.02^*

142.35 ± 3.62^*#&