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Table 1 Effect of each of l-dopa and rasagiline (R) alone or in combination with caffeine (CAF) or coffee (COF) on mean area percentage of neuronal cells and pigmented neurons as well as mean optical density of pigmented neurons in brain tissue sections in paraquat (PQ)-treated mice

From: Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

Groups Mean area percentage Mean optical density
Pigmented neurons
Neuronal cells Pigmented neurons
Control 0.51 ± 0.06 0.31 ± 0.04 99.41 ± 4.80
Paraquat 0.12 ± 0.02* 0.05 ± 0.01* 24.57 ± 1.21*
l-Dopa 0.26 ± 0.03* 0.46 ± 0.07*# 127.83 ± 0.91*#
l-Dopa + CAF 0.44 ± 0.10#$ 0.27 ± 0.04#$ 112.21 ± 5.29*#$
l-Dopa + COF 0.21 ± 0.01*€ 0.24 ± 0.02#$ 116.87 ± 3.25*#
R 0.09 ± 0.03* 0.12 ± 0.02* 166.05 ± 7.42*#
R + CAF 0.13 ± 0.02* 0.16 ± 0.02* 135.83 ± 3.51*#&
R + COF 0.12 ± 0.02* 0.13 ± 0.02* 142.35 ± 3.62*#&
  1. Values are presented as mean ± S.E.M. *Significant from normal group P < 0.05. #Significant from paraquat group P < 0.05. $Significant from l-dopa group P < 0.05. Significant from l-dopa + CAF group P < 0.05. &Significant from R group P < 0.05