Skip to main content

Table 7 Hepatoprotective activity of Costus speciosus against hepatotoxins (Verma and Khosa, 2009; AlSaadi et al. 2018)

From: Phytochemical competence and pharmacological perspectives of an endangered boon—Costus speciosus (Koen.) Sm.: a comprehensive review

Solvent used for extraction Part of Costus speciosus used for extraction Experimental/model animal Hepatotoxin used Histopathological analysis (Hepatocytes) Biochemical analysis (Serum hepatic biomarkers) References
Damages caused by hepatotoxin Recovery through Costus speciosus extract Changes in the level of serum hepatic biomarkers
Due to hepatotoxin When Costus speciosus extract is given
Ethanol Rhizome Wistar Albino Rats CCl4 Necrosis, Fatty lobules accumulation around central vein, inflammatory collections Liver architecture almost normal, significant reduction of inflammatory cellular infiltrations (when 500 mg/kg of ethanolic used) SGPT ↑
SGOT↑
ALP↑
Serum Bilirubin↑
Liver Damage
SGPT ↓
SGOT ↓
ALP ↓
Serum Bilirubin↓
Recovery of liver
Verma and Khosa (2009)
Methanol Rhizome Adult Albino Mice Paracetamol Congestion of liver cells, necrosis, apoptosis Significant improvement in liver architecture, no necrosis or inflammation (when 200 mg/kg was used) AST ↑
ALP ↑
ALT ↑
TNF-α ↑
AST ↓
ALP ↓
ALT ↓
TNF-α ↓
AlSaadi et al. (2018)