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Table 4 Effect of ethanolic extract (MAE) of Carica papaya on lipid profile in hyperlipidemic rats

From: The influence of the extraction method on polyphenols, flavonoids composition and anti-hyperlipidemic properties of papaya leaves (Carica papaya Linn.)

Parameter

Groups

Experiment duration

Negative

gp

Positive

gp

Papaya extract

(100 mg/kg) gp

Papaya extract

(200 mg/kg) gp

Simvastatin

(reference gp)

Cholesterol

Zero

91.8 ± 2.1

162.3 ± 5.4

168.7 ± 5.1

171.2 ± 4.3

195.4 ± 3.6

4 weeks

92.7 ± 2.3

184.2 ± 5.6a

136.8 ± 4.3a

112.3 ± 3.8a

128.1 ± 3.4a

8 weeks

89.6 ± 1.9

189.4 ± 5.5a

111.2 ± 3.7a

98.6 ± 2.4a

94.7 ± 2.2a

Triglycerides

Zero

57.8 ± 1.5

83.8 ± 2.1

89.2 ± 2.5

88.6 ± 1.8

86.3 ± 1.7

4 weeks

59.2 ± 1.3

92.2 ± 3.4a

76.7 ± 2.8a

69.1 ± 2.1a

73.4 ± 1.2a

8 weeks

58.7 ± 1.4

98.3 ± 5.7a

68.3 ± 2.2a

61.4 ± 1.9a

58.1 ± 1.3a

LDLC

Zero

37.9 ± 0.6

117.4 ± 4.6a

127.0 ± 4.3

130.6 ± 4.9a

154.5 ± 6.2

4 weeks

37.3 ± 0.4

141.2 ± 4.8a

93.6 ± 3.2a

51.2 ± 1.8a

80.5 ± 2.4a

8 weeks

35.8 ± 0.5

147.0 ± 3.9a

68.2 ± 2.4a

46.5 ± 1.9a

41.7 ± 1.9a

HDLC

Zero

42.3 ± 0.9

28.3 ± 0.6

23.9 ± 0.3

22.9 ± 0.8

23.6 ± 0.7

4 weeks

43.6 ± 0.1

24.6 ± 0.3a

28.2 ± 0.6

33.6 ± 1.2a

32.9 ± 0.8a

8 weeks

42.1 ± 0.8

22.7 ± 0.4a

32.7 ± 0.4

39.8 ± 1.3a

41.6 ± 1.2a

AI

Zero

0.90

1.60

5.30

5.70

6.60

4 weeks

0.86

5.70

3.30

1.50

2.50

8 weeks

0.85

6.50

2.10

1.20

0.96

  1. aSignificantly different from zero time at P < 0.01
  2. All values: Mean ± S.E
  3. AI = LDLC/HDLC