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Table 4 Effect of ethanolic extract (MAE) of Carica papaya on lipid profile in hyperlipidemic rats

From: The influence of the extraction method on polyphenols, flavonoids composition and anti-hyperlipidemic properties of papaya leaves (Carica papaya Linn.)

Parameter Groups
Experiment duration Negative
gp
Positive
gp
Papaya extract
(100 mg/kg) gp
Papaya extract
(200 mg/kg) gp
Simvastatin
(reference gp)
Cholesterol
Zero 91.8 ± 2.1 162.3 ± 5.4 168.7 ± 5.1 171.2 ± 4.3 195.4 ± 3.6
4 weeks 92.7 ± 2.3 184.2 ± 5.6a 136.8 ± 4.3a 112.3 ± 3.8a 128.1 ± 3.4a
8 weeks 89.6 ± 1.9 189.4 ± 5.5a 111.2 ± 3.7a 98.6 ± 2.4a 94.7 ± 2.2a
Triglycerides
Zero 57.8 ± 1.5 83.8 ± 2.1 89.2 ± 2.5 88.6 ± 1.8 86.3 ± 1.7
4 weeks 59.2 ± 1.3 92.2 ± 3.4a 76.7 ± 2.8a 69.1 ± 2.1a 73.4 ± 1.2a
8 weeks 58.7 ± 1.4 98.3 ± 5.7a 68.3 ± 2.2a 61.4 ± 1.9a 58.1 ± 1.3a
LDLC
Zero 37.9 ± 0.6 117.4 ± 4.6a 127.0 ± 4.3 130.6 ± 4.9a 154.5 ± 6.2
4 weeks 37.3 ± 0.4 141.2 ± 4.8a 93.6 ± 3.2a 51.2 ± 1.8a 80.5 ± 2.4a
8 weeks 35.8 ± 0.5 147.0 ± 3.9a 68.2 ± 2.4a 46.5 ± 1.9a 41.7 ± 1.9a
HDLC
Zero 42.3 ± 0.9 28.3 ± 0.6 23.9 ± 0.3 22.9 ± 0.8 23.6 ± 0.7
4 weeks 43.6 ± 0.1 24.6 ± 0.3a 28.2 ± 0.6 33.6 ± 1.2a 32.9 ± 0.8a
8 weeks 42.1 ± 0.8 22.7 ± 0.4a 32.7 ± 0.4 39.8 ± 1.3a 41.6 ± 1.2a
AI
Zero 0.90 1.60 5.30 5.70 6.60
4 weeks 0.86 5.70 3.30 1.50 2.50
8 weeks 0.85 6.50 2.10 1.20 0.96
  1. aSignificantly different from zero time at P < 0.01
  2. All values: Mean ± S.E
  3. AI = LDLC/HDLC