QSAR, molecular docking studies, ligand-based design and pharmacokinetic analysis on Maternal Embryonic Leucine Zipper Kinase (MELK) inhibitors as potential anti-triple-negative breast cancer (MDA-MB-231 cell line) drug compounds

Bulletin of the National Research Centre

Table 6 Suggested values used in the assessment of QSAR model

Characters	Names	Values
R²	Coefficient of determination	≥ 0.6
P_(95%)	Confidence interval at 95% confidence level	< 0.05
Q²	Squared cross-validation coefficient	≥ 0.5
R²-Q²	Difference between R² and Q²	< 0.3
N_{test set}	Least number of the test set	≥ 5
R²_ext	Coefficient of determination of external validation	≥ 0.5