Antagonistic effects of some commonly used herbs on the efficacy of Artemisinin derivatives in the treatment of malaria in experimental mice

Bulletin of the National Research Centre

Table 2 Mean percentage parasitaemia of mice treated with single therapy

Treatment Grps	Day1	Day2	Day3	Day4	Day5	Day6
M. morindiodes	23.25 ± 0.29^a	21.83 ± 0.29^c	20.38 ± 0.29^c	11.72 ± 0.13^c	10.25 ± 0.04^b	4.21 ± 0.11^b
M. lucida	27.73 ± 0.04^d	26.73 ± 0.04^d	24.98 ± 0.04^d	18.18 ± 0.11^d	10.99 ± 0.56^b	6.99 ± 0.02^c
V. amygdalina	29.07 ± 0.02^e	28.20 ± 0.18^e	23.81 ± 0.33^d	19.15 ± 0.60^e	18.34 ± 0.67^c	17.38 ± 0.60^d
Artesunate	26.38 ± 0.13^c	20.76 ± 0.13^b	10.05 ± 0.13^b	3.26 ± 0.07^b	0.00 ± 0.00^a	0.00 ± 0.00^a
Chloroquine	25.75 ± 0.13^b	17.48 ± 0.13^a	8.56 ± 0.13^a	2.5 ± 0.07^a	0.00 ± 0.00^a	0.00 ± 0.00^a
Untreated	29.88 ± 0.13^f	30.43 ± 0.13^f	30.71 ± 0.13^e	31.14 ± 0.00^f	33.05 ± 0.00^d	32.67 ± 0.07^e

Values were expressed as mean ± standard deviation (SD). Values with different superscripts (Alphabets) in a column are significantly different (p < 0.05) from each other. This implies that for each day, values with superscript a are the least value, followed by b then c, d e to f (highest). For example, at day 1, the lowest values for percentage parasitaemia were recorded in mice treated with M. morindiodes followed by that of chloroquine, while the highest parasitaemia was in untreated mice. These differences are statistically significant (all the values did not have similar superscript). At days 5 and 6, mice treated with artesunate and chloroquine have the least values for parasitaemia and both the same superscripts (a). This means they are not significantly different from one another
Mean values were from five mice observed in each group