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Table 3 Cumulative inhibition/activation of poly-dHbS-M by fractionated leaf extracts of A. occidentale, P. guajava, and T. catappa

From: Polymerization of deoxygenated sickle hemoglobin in the presence of fractionated leaf extracts of Anacardium occidentale, Psidium guajava, and Terminalia catappa

Extract fraction AUC ×103 (%.second)/RCPI (%)
Control 40 mg% 60 mg% 80 mg%
A. occidentale  
Petroleum ether 15.12 ± 2.08a (100) 14.54 ± 2.57a,b (3.8) 13.09 ± 8.32c,d (13.4) 13.51 ± 6.53a,b,c (10.7)
n-hexane 22.21 ± 1.48a,b (100) 23.29 ± 10.33a (4.9)↑ 21.97 ± 11.34a,b,c (1.1) 20.17 ± 9.61c,d (9.2)
Chloroform 22. 36 ± 2.02c (100) 30.54 ± 16.59a (36.6)↑ 26.71 ± 7.09a,b (19.5)↑ 19.44 ± 7.17d (13.1)
Ethylacetate 22.21 ± 1.48a,b (100) 9.02 ± 5.54d (59.4) 13.33 ± 4.39c (40.0) 23.18 ± 14.34a (4.4)↑
Residual aqueous 16.65 ± 2.00d (100) 31.65 ± 9.00c (90.1)↑ 93.78 ± 6.35a (463.2)‡ 52.12 ± 19.87b (213.0)‡
P. guajava
Petroleum ether 22.36 ± 2.02d (100) 34.53 ± 14.00a (54.4)↑ 32.83 ± 12.82a,b(46.8)↑ 31.62 ± 16.78a,b,c (41.4)↑
n-hexane 15.12 ± 2.08a (100) 9.69 ± 4.00b,c (35.9) 10.99 ± 3.10b (27.3) 8.98 ± 2.24b,c,d (40.6)
Chloroform 15.12 ± 2.08a (100) 13.56 ± 1.45b,c (10.3) 13.05 ± 9.63b,c,d (13.7) 13.77 ± 2.94b (8.9)
Ethylacetate 15.12 ± 2.08b (100) 9.86 ± 3.69c,d (34.8) 16.74 ± 10.00a (10.7)↑ 10.99 ± 3.14c (27.3)
Residual aqueous 16.65 ± 2.00c (100) 16.49 ± 3.26c,d (1.0) 19.09 ± 3.95b (14.7)↑ 23.87 ± 1.35a (43.4)↑
T. catappa
Petroleum ether 12.53 ± 2.11c,d (100) 16.36 ± 5.88a,b (30.6)↑ 16.51 ± 5.07a (31.8)↑ 13.32 ± 3.25c (6.3)↑
n-hexane 13.85 ± 5.93a,b (100) 13.40 ± 5.29a,b,c (3.3) 13.00 ± 6.80a,b,c,d (6.1) 14.03 ± 1.09a (1.3)↑
Chloroform 13.85 ± 5.92a,b (100) 14.37 ± 2.02a (3.8)↑ 13.53 ± 2.00a,b,c (2.3) 12.81 ± 1.98,c,d (7.5)
Ethylacetate 13.85 ± 5.92a,b (100) 14.52 ± 1.32a (4.8)↑ 12.18 ± 3.48c (12.1) 7.78 ± 2.12d (43.8)
Residual aqueous 16.65 ± 2.00b,c (100) 21.05 ± 1.08a (26.4)↑ 17.68 ± 6.75b (6.2)↑ 16.61 ± 5.00b,c,d (0.2)
  1. The mean (X) ± S.D of three (n = 3) determinations; mg% = mg/100 mL. Means in the row with the same letter are not significantly different at p > 0.05 according to LSD
  2. : Cumulative activation of poly-dHbS-M
  3. ‡: RCPI%Test > RCPI%Control