Histological changes in the cecum of rats infected with E. histolytica 7 days post-infection. A Showed the trophozoite (T) attached to the surface epithelial layer. H&E stain, ×948. B Showed destruction of epithelial layer (D) and hyperplasia of crypts (C). H&E stain, ×40. C Showed destruction of mucosa (M), degeneration of interglandular epithelium (D), heavy infiltration of inflammatory cells within lamina propria (F) H&E stain, ×379.