Effects of nano-curcumin on gene expression of insulin and insulin receptor

Bulletin of the National Research Centre

Table 1 Effects of nano-curcumin and Diamicron on glucose, insulin, and glycated hemoglobin of Streptozotocin-induced diabetic rats

Variables	NC (group I)	DC (group II)	Diab-Diam (group III)	Diab-Cur (group IV)
Glucose (mg/dl)
Start	104.67 ± 8.4	243^a ± 12.6	241.67^a ± 6.5	244.75^a ± 8
Final	102.58 ± 4.9	348.8^a ± 11.3	149.5^ab ± 5	158.75^ab ± 5.08
Insulin (mIU/ml)
Start	13.26 ± 0.22	9.04^a ± 0.23	9.39^a ± 0.27	9.04^a ± 0.37
Final	13.6 ± 0.29	7.95^a ± 0.54	11.22^ab ± 0.28	10.92^ab ± 0.38
HbA1C (%)	5.97 ± 0.36	8.96^a ± 0.28	7^ab ± 0.40	7.25^ab ± 0.27

Values are expressed as mean ± SD for each group, n = 10 for each group
NC negative control, DC diabetic control group, Diab-Diam treatment group (fed a normal diet plus diamicron), Diab-Cur treatment group (fed a normal diet plus curcumin)
^aValues are significantly different from negative control (P < 0.05)
^bValues are significantly different from diabetic control group (P < 0.05)