Fig. 3
From: Effects of nano-curcumin on gene expression of insulin and insulin receptor
Histopathological graphs showing a liver of normal rat (negative control) with normal blood sinusoids, normal histoarchitecture, and hepatic cords with normal appearance and distribution of Kuppfer cells (KC). b A photomicrograph of liver of diabetic rat showing Kupffer cells activation and cytoplasmic vacuolization of hepatocytes, dilatation of liver sinusoids, and some necrotic changes of liver tissue. c Liver of Diamicron-treated group showing moderate blood sinusoids (BS) with mild increased of Kupffer cells, mild necrotic changes, normal tissue histoarchitecture, and normal hepatic cords. d Liver of curcumin-treated group showing normal tissue histoarchitecture with mild dilatation of blood sinusoids, mild increase in number and distribution of Kuppfer cells, moderate fatty changes (FCH), and moderate necrotic changes (NT)