Table 1 The neuromodulatory role of grape-derived polyphenols in AD animal models
Grape supplementation | AD subject | Therapeutic outcomes | Reference |
|---|---|---|---|
Grape seed-derived polyphenolic extract | Tg2576 mice | Anti-amyloidogenic Attenuated cognitive deterioration | Wang et al. 2008 |
Grape seed-derived polyphenols | Tg2576 mouse model of AD | Anti-amyloidogenic Memory-enhancing | Ono et al. 2008 |
Resveratrol-supplemented diet | Adult and aged mice | Anti-inflammatory | Abraham and Johnson 2009 |
Hydroalcoholic extract of grape | AlCl3-induced AD rats | Memory enhancing Improved locomotion and muscular activity Anti-oxidative Neuroprotective | Lakshmi et al. 2014 |
Resveratrol | Tg19959 mice | Anti-oxidative Anti-amyloidogenic | Karuppagounder et al. 2009 |
Grape-derived polyphenols | AD-mice | Anti-aggregation Anti-phosphorylation of tau protein | |
Grape leaves extracts (organic and conventional) | Hydrogen peroxide-induced brain of rats | Neuroprotective | Dani et al. 2010 |
Grape seed polyphenolic extract | AD-mice | Modulating tau-mediated neuropathological mechanisms | Ho and Pasinetti 2010 |
Grape seed proanthocyanidin | Adult (3 months) and middle-aged (12 months) rats | Anti-oxidative Neuroprotective Memory enhancing Cholinergic activity Memory enhancing | Devi et al. 2011 |
Grape seed polyphenolic extract | Tg2576 mice | Anti-amyloidogenic Attenuated cognitive impairment and AD-neuropathology in the brains of transgenic mice | Liu et al. 2011 |
Grape seed polyphenolic extract (GSPE) | Tg JNPL3 mice (expressing a Human tau protein) | Anti-tau pathology Improvement in the Motor function | Santa-Maria et al. 2012 |
Quercetin-3-O-glucuronide | Tg2576 AD mouse model | Anti-amyloidogenic | Ho et al. 2013 |
Resveratrol | 8–9-month-old mice | Neurotrophic (BDNF) support Improved learning and memory | Zhao et al. 2013 |
Resveratrol | AD rats | Anti-amyloidogenic Anti-inflammatory Neuroprotective | Zhao et al. 2015 |
Grape leaves polyphenols | AlCl3-induced AD rats | Anti-oxidative Anti-cholinesterase Anti-inflammatory Neurotrophic (BDNF) support | Borai et al. 2017 |
Resveratrol | AD-mice | Enhanced neurocognitive function through facilitating transplantation of hUC-MSCs into the brains of AD mice | Wang et al. 2018 |
Grape leaves polyphenols | AlCl3-induced AD rats | Anti-amyloidogenic Anti-oxidative Hypolipidemic Anti-aging | Rizk et al. 2018 |
Resveratrol | Aβ-induced mice | Anti-amyloidogenic Improved memory function | Qi et al. 2019 |
Resveratrol | SAMP8 AD-mice | Increased antioxidant capacity through the Nrf2/HO-1 signaling pathway | Kong et al. 2019 |