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Table 1 The neuromodulatory role of grape-derived polyphenols in AD animal models

From: Possible neuromodulating role of different grape (Vitis vinifera L.) derived polyphenols against Alzheimer’s dementia: treatment and mechanisms

Grape supplementation AD subject Therapeutic outcomes Reference
Grape seed-derived polyphenolic extract Tg2576 mice Anti-amyloidogenic
Attenuated cognitive deterioration
Wang et al. 2008
Grape seed-derived polyphenols Tg2576 mouse model of AD Anti-amyloidogenic
Ono et al. 2008
Resveratrol-supplemented diet Adult and aged mice Anti-inflammatory Abraham and Johnson 2009
Hydroalcoholic extract of grape AlCl3-induced AD rats Memory enhancing
Improved locomotion and muscular activity
Lakshmi et al. 2014
Resveratrol Tg19959 mice Anti-oxidative
Karuppagounder et al. 2009
Grape-derived polyphenols AD-mice Anti-aggregation
Anti-phosphorylation of tau protein
Wang et al. 2010a, 2010b
Grape leaves extracts (organic and conventional) Hydrogen peroxide-induced brain of rats Neuroprotective Dani et al. 2010
Grape seed polyphenolic extract AD-mice Modulating tau-mediated neuropathological mechanisms Ho and Pasinetti 2010
Grape seed proanthocyanidin Adult (3 months) and middle-aged (12 months) rats Anti-oxidative
Memory enhancing
Cholinergic activity
Memory enhancing
Devi et al. 2011
Grape seed polyphenolic extract Tg2576 mice Anti-amyloidogenic
Attenuated cognitive impairment and AD-neuropathology in the brains of transgenic mice
Liu et al. 2011
Grape seed polyphenolic extract (GSPE) Tg JNPL3 mice (expressing a Human tau protein) Anti-tau pathology
Improvement in the Motor function
Santa-Maria et al. 2012
Quercetin-3-O-glucuronide Tg2576 AD mouse model Anti-amyloidogenic Ho et al. 2013
Resveratrol 8–9-month-old mice Neurotrophic (BDNF) support
Improved learning and memory
Zhao et al. 2013
Resveratrol AD rats Anti-amyloidogenic
Zhao et al. 2015
Grape leaves polyphenols AlCl3-induced AD rats Anti-oxidative
Neurotrophic (BDNF) support
Borai et al. 2017
Resveratrol AD-mice Enhanced neurocognitive function through facilitating transplantation of hUC-MSCs into the brains of AD mice Wang et al. 2018
Grape leaves polyphenols AlCl3-induced AD rats Anti-amyloidogenic
Rizk et al. 2018
Resveratrol Aβ-induced mice Anti-amyloidogenic
Improved memory function
Qi et al. 2019
Resveratrol SAMP8 AD-mice Increased antioxidant capacity through the Nrf2/HO-1 signaling pathway Kong et al. 2019
  1. amyloid beta, AD Alzheimer’s disease, Tg transgenic, AlCl3 aluminum chloride, hUC-MSCs human umbilical cord mesenchymal stem cells, Nrf2 nuclear factor erythroid 2-related factor 2, BDNF brain-derived neurotrophic factor