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Table 2 Effect of ethanolic extract of Rosmarinus officinalis (EERO) on, SOD, CAT, GSH, GPx, LPO, and XOD in CCl4-induced nephrotoxicity in rats

From: Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

Groups SOD (U/mg) CAT (U/mg) GSH (nM/mg) GPx (U/mg) XOD (IU/gm) LPO (nM/mg)
Control 2.92 ± 0.10 24.49 ± 2.01 533.17 ± 11.94 5.92 ± 0.19 307.86 ± 27.70 0.22 ± 0.011
CCl4 1.85 ± 0.18 (− 36.64%) 12.59 ± 1.91 (− 48.59%) 310.80 ± 9.92 (− 41.70%) 3.97 ± 0.27 (− 32.93%) 615.61 ± 20.19 (+ 99.96%) 0.43 ± 0.04 (+ 95.45%)
EERO 100 mg/kg 2.73 ± 0.14 (− 6.50%) 22.51 ± 2.10 (− 8.08%) 526.88 ± 15.23 (− 1.17%) 5.93 ± 0.09 (+ 0.16%) 321.02 ± 16.70 (+ 4.28%) 0.26 ± 0.01 (+ 18.18%)
EERO 250 mg/kg 2.71 ± 0.11 (− 7.19%) 26.25 ± 2.27 (+ 7.18%) 535.76 ± 11.46 (+ 0.48%) 5.94 ± 0.11 (+ 0.33%) 315.73 ± 21.76 (+ 2.55%) 0.25 ± 0.01 (+ 13.63%)
EERO 100 mg/kg + CCl4 2.36 ± 0.17** (− 19.17%) 17.93 ± 2.07* (− 26.78%) 506.90 ± 15.48** (− 4.92%) 5.75 ± 0.19** (− 2.87%) 351.27 ± 27.12** (+ 14.10%) 0.30 ± 0.013** (+ 36.36%)
EERO 250 mg/kg + CCl4 2.57 ± 0.11** (− 11.98%) 21.04 ± 1.85** (− 14.08%) 520.22 ± 15.10** (− 2.42%) 5.86 ± 0.13** (− 1.01%) 325.69 ± 23.72** (+ 5.79%) 0.24 ± 0.01** (+ 9.09%)
  1. All data presented in Mean ± SD (n = 6) and *P < 0.05 (significant) **P < 0.001 (highly significant) as compared to control group. + = % increase, −=% decrease, all groups were compared with control group which received distilled water for 30 days orally