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Table 1 Effect of ethanolic extract of upper shoot of Rosmarinus officinalis (EERO) on BUN, urea, and creatinine in CCl4-induced nephrotoxicity in rats

From: Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

Groups BUN (mg/dl) Creatinine (mg/dl)
Control 17.99 ± 1.20 0.88 ± 0.14
CCl4 39.62 ± 3.20 (+ 120.23%) 2.08 ± 0.21 (+ 136.36%)
EERO 100 mg/kg 19.47 ± 1.92 (+ 8.22%) 0.97 ± 0.10 (+ 10.22%)
EERO 250 mg/kg 18.10 ± 1.55 (+ 0.61%) 0.96 ± 0.21 (+ 9.09%)
EERO 100 mg/kg + CCl4 22.19 ± 2.12** (+ 23.34%) 1.07 ± 0.17** (+ 21.59%)
EERO 250 mg/kg + CCl4 18.56 ± 1.31** (+ 3.16%) 1.02 ± 0.11** (+ 15.90%)
  1. All data presented in Mean ± SD (n = 6) and **P < 0.001 (highly significant) as compared to CCl4 group. + = % increase, − = % decrease, all groups were compared with control group which received distilled water for 30 days orally