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Table 5 Results of the articles included in the review about the effect of the application of antibiotics for the treatment of apical periodontitis

From: Antibiotics for treatment of apical periodontitis, indication or contraindication

No.

Study authors

Pathology

Medicament

Conclusions

1

Molander et al. (1990)

PA

 

Clindamycin

2 distance application sessions 7 days

There are no advantages!

2

Walton and Chiappinelli (1993)

 

PAA

Penicillin

There are no advantages!

3

Paterson and Curzon (1993)

 

PAS

Amoxicillin Penicillin

Amoxicillin more effective than penicillin!

4

Fouad et al. (1996)

 

PAS

Penicillin

There are no advantages!

5

Fava (1998)

 

PAS

Minocycline corticosteroid

There are no advantages!

6

Danin et al. (2003)

PA

 

Linezolid

The tissue indicator Il-1RA is an indicator of the effectiveness of the antibiotic

7

Ehrmann et al. (2003)

 

PAS

Ledermix

Faster pain reduction compared to calcium hydroxide

8

Chu et al. (2006)

PA

 

Ledermix Streptomycin

Does not significantly reduce gram + facultative anaerobic cocci!

9

Bhangdia et al. (2013)

 

PAA

Metronidazole 3–0.5%

3% w/v more effective than 0.5% w/v against E. faecal

10

Arruda et al. (2018)

 

PAA

1 mg/ml antibiotic paste Minocycline metronidazole Ciprofloxacin

Positive effect after 1 week placed inside the channel!

11

Samir Abouelenien et al. (2018)

PA

 

Minocycline metronidazole

Postoperative pain is reduced despite the canal being treated only with excision!

12

AbdurRahman et al. (2019)

PA

 

1 mg/ml antibiotic paste Minocycline metronidazole Ciprofloxacin

Some resets after 1, 2, 3 days, 1 week, neutral effect!

13

Karataş et al. (2020)

 

PAA

Ciprofloxacin 50 mg + 950 mg calcium hydroxide + 1 mL Propylene glycol

Positive effects after placement with = duration 1 week 1 mm shorter than working length!

14

Ali et al. (2020)

 

PAS

Minocycline metronidazole Ciprofloxacin

Antibiotic paste has the same effect as calcium hydroxide—dexamethasone!