Discussion of field effects after intraovarian injection of autologous platelet-rich plasma

Bulletin of the National Research Centre

Table 1 Ovary components by cell type and corresponding response to platelet-rich plasma or platelet (PLT) derivatives, based on reported corollary observations in each group

Classification	PLT protocol	Field effect	Refs
Endothelial	N	PDGF-B & ICAM-1 expression, cell migration	Cenni et al. 2009)
Granulosa	+ hMSC	↑ proliferation, ↓ apoptosis	Wang et al. 2021)
Immune	N	macrophage & neutrophil activation	Scopelliti et al. 2022)
Oocyte	N	↑ mitochondrial activity	Moulavi et al. 2020)
Perivascular	N	↑VEGF, ↑ CD34 expression, ↑ perfusion	Liu et al. 2022)
Stroma	EGF, MMP-2 & 9	epithelial → mesenchymal transition	Ahmed et al. 2006)
Germline stem	Pending	Undefined	–

N = neat (unfractionated), PDGF-B = platelet derived growth factor subunit B, ICAM-1 = intercellular adhesion molecule-1 (CD54), hMSC = human mesenchymal cells, VEGF = vascular endothelial growth factor, CD34 = hematopoietic progenitor cell marker, EGF = epidermal growth factor, MMP = matrix metalloproteinase