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Table 3 TC epitopes with its binding allele (IC50 < 500 nM)

From: Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach

S.no

CTL epitope

Position

Allele

Proteasome score

TAP score

Processing score

IC50

Antigenicity (VaxiJen score)

1

LRFIVIMIV

Bm-FAB-1 (3–11)

HLA-C*12:03

0.92

0.29

1.21

10.9

1.6738

HLA-C*07:01

32.6

HLA-C*06:02

232.2

HLA-C*14:02

235.3

2

FLGTFVLER

Bm-FAB-1 (35–43)

HLA-C*12:03

1.06

0.58

1.64

32.4

0.8245

HLA-C*03:03

78.1

HLA-C*14:02

215.1

HLA-A*68:01

218

HLA-A*31:01

313.7

HLA-A*02:01

328.2

HLA-B*15:02

437.8

3

NTLFAEWAL

Bm-FAB-1 (94–102)

HLA-C*03:03

1.45

0.48

1.93

14.4

0.6420

HLA-B*15:02

59.2

HLA-C*12:03

163

HLA-A*68:02

186.5

HLA-C*14:02

200.3

HLA-A*02:06

225.2

4

DNPRDIETY

Bm-FAB-1 (137–145)

HLA-C*12:03

1.48

1.08

2.56

12.7

0.6283

HLA-C*14:02

150.2

HLA-C*03:03

452.5

HLA-B*15:02

477.8

5

DALAVFIDK

Thioredoxin family protein (164–172)

HLA-C*03:03

0.67

0.12

0.79

11.5

0.5056

HLA-C*12:03

25.7

HLA-A*68:01

144.7

HLA-C*14:02

188.2

HLA-A*11:01

436.8

6

AEELTEEGL

Thioredoxin family protein (287–295)

HLA-B*40:01

1.47

0.42

1.89

37.1

1.1538

HLA-C*12:03

57.6

HLA-C*03:03

65.6

HLA-B*15:02

155.3

HLA-C*05:01

173.6

7

LNSNERIEY

Thioredoxin family protein (249–257)

HLA-C*12:03

1.43

1.14

2.57

22.8

0.5401

HLA-C*03:03

28.1

HLA-C*14:02

240.8

HLA-A*29:02

428.3

HLA-B*35:01

485.9

8

LIAFGLVIL

ALT2 (5–13)

HLA-C*03:03

1.54

0.5

2.04

45.8

0.7180

HLA-B*15:02

74

HLA-C*12:03

122.5

HLA-A*02:06

239.1

HLA-A*02:01

336.6

9

RQGIGENVY

Venom allergen antigen-like protein 1 (93–101)

HLA-C*12:03

1.61

1.32

2.92

18.5

1.1047

HLA-B*15:01

59.4

HLA-A*30:02

140.1

HLA-C*03:03

229.4

HLA-C*05:01

415.6

10

KGKWLILFF

Peroxiredoxin 1 (61–69)

HLA-C*12:03

1.51

1.01

2.52

17.5

1.6196

HLA-A*30:01

209.4

HLA-B*15:02

436.7

11

ADDITICGF

Transglutaminase (154–162)

HLA-C*12:03

1.36

0.94

2.29

17.1

1.9539

HLA-C*05:01

61.8

HLA-C*08:02

162.6

HLA-B*15:02

187.6

HLA-C*14:02

191.3

12

ADTERDRFK

Transglutaminase (177–185)

HLA-C*03:03

0.82

0.14

0.96

21.3

0.8263

HLA-C*12:03

48.3

13

SNYWRNRVL

Transglutaminase (276–284)

HLA-C*03:03

1.64

0.44

2.08

13.1

2.2390

HLA-B*15:02

30.2

HLA-C*12:03

50

HLA-C*14:02

55.2

HLA-C*15:02

66.7

HLA-C*07:01

69.4

HLA-C*06:02

172.5

HLA-B*14:02

392.7

14

VLIEFYAPW

Transglutaminase (390–398)

HLA-C*12:03

0.98

0.39

1.36

27.6

0.9901

HLA-C*03:03

32.9

HLA-C*14:02

119.8

HLA-B*58:01

158.2

HLA-A*32:01

173.4

HLA-A*02:01

189.3

HLA-A*02:06

384.2

HLA-B*57:01

484

15

GREVDDFIK

Transglutaminase (463–471)

HLA-C*12:03

1.03

0.14

1.17

41.1

0.4956

HLA-C*03:03

286.2

HLA-C*07:01

309.2

HLA-C*14:02

489.4