Fig. 2
From: NLRP3 inflammasome as a novel target for cystic fibrosis treatment
Immunometabolism of neutrophils in cystic fibrosis. Irregularity in the transport of Na+ and Cl− in the lung epithelial cells of patients with CF is shown in the figure. In addition, an inflammation originating from PAMPs and DAMPs begins in neutrophils in lung cells, where the CFTR protein cannot show proper activity. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license. Figure inset from (Cantin 2019) licensed under Creative Commons Attribution, Non-Commercial, No Derivatives License 4.0. ENaC epithelial sodium channel, DAMPs Damage-associated molecular patterns, NF-κB Nuclear factor-κB, PAMPs Pathogen-associated molecular patterns, PPARγ Peroxisome proliferator-activated receptor-γ, TLR Toll-like receptors