Table 5 LC-MS/MS, LC-MS methods for analysis of FDA-approved treatments for several cardiovascular illnesses from 2015 to June 2020
Stationary phase | Mobile phase (v/v) | Applications |
|---|---|---|
C-18 column (LC–MS/MS) | 5 mm ammonium formate in water:Acetonitrile (95:5) | Determination of betrixaban in tablets (Jasemizad and Padhye 2019) |
C-18 column | Acetonitrile:10 mm ammonium formate (80:20) | Determination of selexipag in human plasma (Bhadru et al. 2019) |
C-18 column | Mathanol:5 mm ammonium formate (75:25) | Determination of selexipag in human plasma (Satheshkumar and Muruganantham 2021) |
C-18 column | 1% formic acid: Acetonitrile | Determination of selexipag and its impurities in rat plasma (Rao et al. 2021) |
C-18 column | 0.1% formic acid in mili Q water, 0.1% formic acid in acetonitrile | Simultaneous estimation of sacubitril and valsartan in rat plasma (Chunduri and Dannana 2016) |
C-18 column | Methanol: 0.1% formic acid (80:20) | Estimation of Valsartan in Human Plasma (Chinthala et al. 2017) |