Table 2 Spectrophotometric methods for analysis of FDA-approved treatments for several cardiovascular illnesses from 2015 to June 2020
Method | Solvent system | Linearity (µg/ml) | λ max | Applications |
|---|---|---|---|---|
Direct UV | Methanol: Water: phosphate buffer (pH 9) | 10–60 | 298 | Estimation of selexipag in tablets (Prathyusha et al. 2020) |
Direct UV | Methanol: Water | 5–30 | 600 | Estimation of selexipag in tablets (Gorumutchu and Ratnakaram VN. 2018) |
Direct UV | P-nitroanaline:1 N HCl: Distilled water | 2–12 | 510 | Determination of diazo coupling for selexipag in tablets (Ratnakaram 2018) |
Direct UV | Methanol | 2.5–25 | 226 | Estimation of sacubitril in tablets (Naazneen and Sridevi 2017) |
Direct UV | Methanol | 4–12 | 226 | Estimation of sacubitril in tablets (Kajal and Archana 2022) |
Direct UV | Methanol: Water (25:75) | 2–12 | 242 | Determination of sacubitril in synthetic mixture (Leela Madhuri et al. 2019) |
Direct UV | Methanol | 2–14 | 230 | Determination of sacubitril in combined dosage forms (Banu et al. 2021) |
Direct UV | Methanol | 4.9–24.5 | 242 | Determination of sacubitril in bulk and dosage forms (Murugan and Vetrichelvan 2019) |
Hybrid Spectrofluorimetry | Methanol | 20–200 | 204 | Determination of sacubitril in LCZ696 (Youssef et al. 2021) |
Emission Spectroscopy | Methanol | 0.04–0.8 | 314 | Determination of sacubitril in LCZ696 (Ragab et al. 2017 Dec) |
Direct UV | Water | 10–30 | 276 | Estimation of ivabradine in bulk and dosage forms (Thete and Saudagar 2018) |
Q-absorbance ratio | Methanol | 2–10 | 286 | Estimation of ivabradine in bulk and dosage forms (Patil et al. 2016) |
Direct UV | Methanol | 2–10 | 291.2 | Determination of edoxaban in dosage forms (Ravisankar et al. 2018) |
Direct UV | Methanol | 4–24 | 290 | Determination of edoxaban in tablets (Dhiware et al. 2019) |
Direct UV | Methanol | 5–25 | 289 | Estimation of edoxaban in synthetic mixture (Kalyankar et al. 2018) |
Direct UV | Methanol | 1–20 | 229.4 | Determination of betrixaban in greenness assessment (El-Masry et al. 2022) |
Direct UV | Phosphate buffer 6.8 | 5–30 | 220 | Estimation of valsartan in bulk and tablet dosage form (Rao et al. 2013) |
Direct UV | Methanol | 5–30 | 250.80 | Determination of valsartan in pure and in formulation (Tarkase et al. 2010) |