Table 1 Mediators of triglyceride metabolism
Gene defects targets | Physiology |
|---|---|
Lipoprotein lipase (LPL) | Catabolizes TG in non-hepatic tissues |
Apolipoprotein C-II (APOC2) | Essential LPL activator |
Apolipoprotein A-V (APOA5) | Essential LPL activator |
Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 (Gpihbp1) | Mediates the transmembrane transport and binding of LPL |
Lipase Maturation Factor 1 (LMF1) | Involved in folding and expression of LPL |