From: Mechanisms involved in the anticancer effects of sinapic acid
S. No. | References | Cancer type | Model used | Major mechanism/effect | References |
---|---|---|---|---|---|
1 | Balaji et al. (2014) | Colon cancer | Wistar Albino rats | Reduction of tumor incidence, altering lipid peroxides, enhancing cellular antioxidants and modulating the activities of biotransformation enzymes | 27 |
2 | Balaji et al. (2015) | Colon cancer | Wistar Albino rats | Decreasing pre-neoplastic lesions, curbing LPO, improving cellular antioxidants, modulating the activities of bacterial enzymes | 28 |
3 | Hu et al. (2021) | Lung cancer | Swiss albino mice and A549 cell line | Reduction of tumor burden, oxidative damage and inflammation | 31 |
4 | Badr et al. (2019) | Lung and Colon cancer | A549 and Caco-2 cell lines | Regulation of apoptotic pathway and cell cycle arrest | 36 |
5 | Janakiraman et al. (2014) | Laryngeal carcinoma | Hep-2 cell line | Regulation of apoptotic pathway and cell cycle arrest | 35 |
6 | Eruglu et al. (2018) | Prostate cancer | PC-3 and LNCaP cell lines | Prevention of cell proliferation, cell invasion and induction of apoptosis | 53 |
7 | Zhao et al. (2021) | Liver cancer | Hep G2 and SMMC-7721 cell lines | Prevention of cell proliferation, induction of autophagy and apoptosis | 47 |
8 | Eruglu et al. (2017) | Liver cancer | Hep 3B and HepG2 cell lines | Regulation of apoptotic pathway | 57 |
9 | Tungalag et al. (2021) | Neuroblastoma | SH-SY5Y cell line | Regulation of oxidative stress, ER stress, antioxidants and apoptosis pathway | 32 |
10 | Kampa et al. (2004) | Breast cancer | T47D cell line | Regulation of apoptosis and cell cycle arrest | 48 |
11 | Raj Preeth et al. (2019) | Breast cancer | MCF7 and MDA-MB23 cell lines | Reduction of cell proliferation and regulation of angiogenesis | 58 |
12 | Rajendran et al. (2017) | Myeloid leukemia | K562 cell line | Reduction of cell proliferation and regulation of ROS production | 59 |
13 | Kalaimathi and Suresh (2015a) | Buccal pouch carcinoma | Syrian Hamsters | Modulation of antioxidant defense system and regulating the activities of biotransformation enzymes | 29 |
14 | Kalaimathi and Suresh (2015b) | Buccal pouch carcinoma | Syrian Hamsters | Modulation of proteins involved in apoptosis pathway | 60 |
15 | Huang et al. (2021) | Pancreatic cancer | In vivo and in vitro studies | Regulation of cell proliferation, migration and invasion by downregulating AKT/Gsk-3β signal pathway | 19 |