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Table 1 Summary of the anticancer effects of Sinapic acid

From: Mechanisms involved in the anticancer effects of sinapic acid

S. No.

References

Cancer type

Model used

Major mechanism/effect

References

1

Balaji et al. (2014)

Colon cancer

Wistar Albino rats

Reduction of tumor incidence, altering lipid peroxides, enhancing cellular antioxidants and modulating the activities of biotransformation enzymes

27

2

Balaji et al. (2015)

Colon cancer

Wistar Albino rats

Decreasing pre-neoplastic lesions, curbing LPO, improving cellular antioxidants, modulating the activities of bacterial enzymes

28

3

Hu et al. (2021)

Lung cancer

Swiss albino mice and A549 cell line

Reduction of tumor burden, oxidative damage and inflammation

31

4

Badr et al. (2019)

Lung and Colon cancer

A549 and Caco-2 cell lines

Regulation of apoptotic pathway and cell cycle arrest

36

5

Janakiraman et al. (2014)

Laryngeal carcinoma

Hep-2 cell line

Regulation of apoptotic pathway and cell cycle arrest

35

6

Eruglu et al. (2018)

Prostate cancer

PC-3 and LNCaP cell lines

Prevention of cell proliferation, cell invasion and induction of apoptosis

53

7

Zhao et al. (2021)

Liver cancer

Hep G2 and SMMC-7721 cell lines

Prevention of cell proliferation, induction of autophagy and apoptosis

47

8

Eruglu et al. (2017)

Liver cancer

Hep 3B and HepG2 cell lines

Regulation of apoptotic pathway

57

9

Tungalag et al. (2021)

Neuroblastoma

SH-SY5Y cell line

Regulation of oxidative stress, ER stress, antioxidants and apoptosis pathway

32

10

Kampa et al. (2004)

Breast cancer

T47D cell line

Regulation of apoptosis and cell cycle arrest

48

11

Raj Preeth et al. (2019)

Breast cancer

MCF7 and MDA-MB23 cell lines

Reduction of cell proliferation and regulation of angiogenesis

58

12

Rajendran et al. (2017)

Myeloid leukemia

K562 cell line

Reduction of cell proliferation and regulation of ROS production

59

13

Kalaimathi and Suresh (2015a)

Buccal pouch carcinoma

Syrian Hamsters

Modulation of antioxidant defense system and regulating the activities of biotransformation enzymes

29

14

Kalaimathi and Suresh (2015b)

Buccal pouch carcinoma

Syrian Hamsters

Modulation of proteins involved in apoptosis pathway

60

15

Huang et al. (2021)

Pancreatic cancer

In vivo and in vitro studies

Regulation of cell proliferation, migration and invasion by downregulating AKT/Gsk-3β signal pathway

19