Table 1 Binding affinity of aminosalicylic class of NSAIDs with each receptor
From: One of the 5-aminosalicylates drug, mesalamine as a drug repurposing lead against breast cancer
S. no. | Compounds | EGFR | ERα | Aromatase | mTOR | ALOX5 | TopoII | Progest |
|---|---|---|---|---|---|---|---|---|
1 | Mesalamine | − 5.7 | − 6.2 | − 6.0 | − 6.5 | − 6.0 | − 6.6 | − 5.9 |
2 | Sulfasalazine | − 8.0 | − 8.0 | − 9.1 | − 7.9 | − 8.2 | − 8.6 | − 8.0 |
3 | Balsalazide | − 7.3 | − 7.2 | − 8.1 | − 7.2 | − 7.4 | − 7.9 | − 7.5 |
4 | Olsalazine | − 6.9 | − 7.6 | − 7.8 | − 7.2 | − 7.9 | − 9.4 | − 8.4 |