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Fig. 1 | Bulletin of the National Research Centre

Fig. 1

From: A comprehensive in silico exploration of the impacts of missense variants on two different conformations of human pirin protein

Fig. 1

Interactions between pirin and its binding partners. Docking was performed between Fe2+ conformation of pirin and three ankyrin repeat domains (ANK 5-7) of BCL3 (A), as well as, Fe3+ conformation of pirin and Rel homology domain (RHD) of p65 (residues 19-306) (B). The protein–protein complex structures were depicted using PyMOL (Schrodinger and Delano 2020) (Aa and Ba). Pirin is illustrated in deep teal and its partners in hot pink. Protein–protein interfaces are delineated in yellow. Inter-residue interactions are delineated with iCn3D (Wang et al. 2020) (Ab and Bb). Each gray square represents contacts/interactions within 6 (Å). Residues of pirin are displayed in the x-axis and those of its binding partners are in the y-axis

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