Table 2 The design and response of gallic acid-loaded nanoparticles according to the Box–Behnken experimental design
Run | A: X1 lipid concentration | B:X2 Polymer concentration | C:X3 Drug concentration | Y1 (Particle size) | Y2 (Entrapment efficiency) | Y3 (Drug release) |
|---|---|---|---|---|---|---|
1 | 4 | 1 | 20 | 295.4 ± 1.2 | 29.2 ± 3.6 | 40.8 ± 2.1 |
2 | 4 | 0.5 | 20 | 295.2 ± 3.6 | 28.4 ± 4.2 | 42.8 ± 4.1 |
3 | 4 | 1.5 | 20 | 225.4 ± 7.2 | 58.1 ± 5.1 | 55.6 ± 6.2 |
4 | 4 | 0.75 | 20 | 154.4 ± 4.11 | 75.4 ± 2.1 | 90.4 ± 4.1 |
5 | 2 | 1 | 20 | 195.3 ± 4.4 | 68.91 ± 3.5 | 83.4 ± 4.4 |
6 | 2 | 1 | 20 | 265.4 ± 5.2 | 50.2 ± 4.1 | 42.8 ± 4.6 |
7 | 3 | 1 | 20 | 195.5 ± 5.3 | 68.91 ± 2.5 | 84.8 ± 6.1 |
8 | 1 | 1 | 20 | 195.1 ± 7.2 | 68.94 ± 2.9 | 82.9 ± 6.9 |
9 | 4 | 1 | 20 | 225.3 ± 1.5 | 58.5 ± 3.5 | 63.4 ± 7.2 |
10 | 4 | 1 | 20 | 195.2 ± 6.9 | 68.93 ± 5.2 | 84.4 ± 6.4 |
11 | 4 | 1 | 20 | 185.4 ± 4.3 | 46.2 ± 4.6 | 49.4 ± 7.1 |
12 | 4 | 1 | 20 | 190.6 ± 4.2 | 53.4 ± 4.1 | 60.5 ± 4.3 |
13 | 4 | 1 | 5 | 194.7 ± 6.1 | 40.6 ± 6.2 | 40.8 ± 5.1 |
14 | 4 | 1 | 10 | 160.7 ± 5.2 | 73.6 ± 5.1 | 84.6 ± 5.2 |
15 | 4 | 1 | 15 | 260.8 ± 2.6 | 40.3 ± 5.3 | 55.9 ± 7.1 |
16 | 4 | 1 | 20 | 189.5 ± 2.9 | 66.7 ± 5.6 | 82.8 ± 6.4 |
17 | 4 | 1 | 25 | 260.1 ± 3.1 | 42.8 ± 6.2 | 58.2 ± 7.5 |