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Table 2 The design and response of gallic acid-loaded nanoparticles according to the Box–Behnken experimental design

From: Enhancing cellular uptake and membrane permeability of gallic acid for breast cancer therapy via folate-tagged PEGylated iron oxide nanoparticles has theronastic agent

Run A: X1 lipid concentration B:X2 Polymer concentration C:X3 Drug concentration Y1 (Particle size) Y2 (Entrapment efficiency) Y3 (Drug release)
1 4 1 20 295.4 ± 1.2 29.2 ± 3.6 40.8 ± 2.1
2 4 0.5 20 295.2 ± 3.6 28.4 ± 4.2 42.8 ± 4.1
3 4 1.5 20 225.4 ± 7.2 58.1 ± 5.1 55.6 ± 6.2
4 4 0.75 20 154.4 ± 4.11 75.4 ± 2.1 90.4 ± 4.1
5 2 1 20 195.3 ± 4.4 68.91 ± 3.5 83.4 ± 4.4
6 2 1 20 265.4 ± 5.2 50.2 ± 4.1 42.8 ± 4.6
7 3 1 20 195.5 ± 5.3 68.91 ± 2.5 84.8 ± 6.1
8 1 1 20 195.1 ± 7.2 68.94 ± 2.9 82.9 ± 6.9
9 4 1 20 225.3 ± 1.5 58.5 ± 3.5 63.4 ± 7.2
10 4 1 20 195.2 ± 6.9 68.93 ± 5.2 84.4 ± 6.4
11 4 1 20 185.4 ± 4.3 46.2 ± 4.6 49.4 ± 7.1
12 4 1 20 190.6 ± 4.2 53.4 ± 4.1 60.5 ± 4.3
13 4 1 5 194.7 ± 6.1 40.6 ± 6.2 40.8 ± 5.1
14 4 1 10 160.7 ± 5.2 73.6 ± 5.1 84.6 ± 5.2
15 4 1 15 260.8 ± 2.6 40.3 ± 5.3 55.9 ± 7.1
16 4 1 20 189.5 ± 2.9 66.7 ± 5.6 82.8 ± 6.4
17 4 1 25 260.1 ± 3.1 42.8 ± 6.2 58.2 ± 7.5